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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1976-6-2
|
| pubmed:abstractText |
Fifty-five patients with presenile dementia were examined. There were 28 women and 27 men, and the mean age was 59 and 56 years respectively at the time of the study. A large series of psychometric tests was used, and with the aid of age-matched non-demented controls five significantly different cognitive reduction groups could be identified. In the demented patients the regional cerebral blood flow (rCBF) was determined with an eight-detector or 32-detector equipment. There was a rough proportionality between the cognitive reduction and a decrease of the cerebral blood flow (especially the flow in the grey matter). In addition, certain regional flow abnormalities correlated with specific cognitive functions in a manner resembling the cognitive defects found in focal brain lesions in the same region. Thus, patients who showed only memory disturbances demonstrated a focal flow reduction in the temporal region. More severely affected patients, with reduction of verbal abilities and signs of agnosia, showed very low flows in occipito-temporo-parietal parts of the hemisphere. The results offer a principal confirmation of the dynamic field theory concerning the functional organization of the cerebral cortex.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
|
| pubmed:issn |
0007-1250
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
128
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
209-22
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:1252685-Age Factors,
pubmed-meshheading:1252685-Agnosia,
pubmed-meshheading:1252685-Carbon Dioxide,
pubmed-meshheading:1252685-Cerebral Cortex,
pubmed-meshheading:1252685-Cognition Disorders,
pubmed-meshheading:1252685-Dementia,
pubmed-meshheading:1252685-Female,
pubmed-meshheading:1252685-Humans,
pubmed-meshheading:1252685-Male,
pubmed-meshheading:1252685-Memory Disorders,
pubmed-meshheading:1252685-Middle Aged,
pubmed-meshheading:1252685-Neuropsychological Tests,
pubmed-meshheading:1252685-Occipital Lobe,
pubmed-meshheading:1252685-Parietal Lobe,
pubmed-meshheading:1252685-Partial Pressure,
pubmed-meshheading:1252685-Reaction Time,
pubmed-meshheading:1252685-Regional Blood Flow,
pubmed-meshheading:1252685-Space Perception,
pubmed-meshheading:1252685-Speech Disorders,
pubmed-meshheading:1252685-Temporal Lobe
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Cognitive reduction in presenile dementia related to regional abnormalities of the cerebral blood flow.
|
| pubmed:publicationType |
Journal Article
|