Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-1-15
pubmed:abstractText
Formation of tubes of the correct size and shape is essential for viability of most organisms, yet little is understood of the mechanisms controlling tube morphology. We identified a new allele of hairy in a mutagenesis screen and showed that hairy mutations cause branching and bulging of the normally unbranched salivary tube, in part through prolonged expression of huckebein (hkb). HKB controls polarized cell shape change and apical membrane growth during salivary cell invagination via two downstream target genes, crumbs (crb), a determinant of the apical membrane, and klarsicht (klar), which mediates microtubule-dependent organelle transport. In invaginating salivary cells, crb and klar mediate growth and delivery of apical membrane, respectively, thus regulating the size and shape of the salivary tube.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix..., http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hkb protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/crumbs protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/hairy protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/hairy protein, insect, http://linkedlifedata.com/resource/pubmed/chemical/klar protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
879-91
pubmed:dateRevised
2008-10-16
pubmed:meshHeading
pubmed-meshheading:12526813-Animals, pubmed-meshheading:12526813-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:12526813-Cell Division, pubmed-meshheading:12526813-Cell Membrane, pubmed-meshheading:12526813-DNA-Binding Proteins, pubmed-meshheading:12526813-Drosophila, pubmed-meshheading:12526813-Drosophila Proteins, pubmed-meshheading:12526813-Epithelium, pubmed-meshheading:12526813-Homozygote, pubmed-meshheading:12526813-In Situ Hybridization, pubmed-meshheading:12526813-Insect Proteins, pubmed-meshheading:12526813-Membrane Proteins, pubmed-meshheading:12526813-Membrane Transport Proteins, pubmed-meshheading:12526813-Microscopy, Electron, pubmed-meshheading:12526813-Mutagenesis, pubmed-meshheading:12526813-Mutation, pubmed-meshheading:12526813-Phenotype, pubmed-meshheading:12526813-Repressor Proteins, pubmed-meshheading:12526813-Salivary Glands
pubmed:year
2002
pubmed:articleTitle
Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.
pubmed:affiliation
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't