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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-15
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pubmed:abstractText |
Here we describe a novel mechanism for plasma membrane insertion of the delta opioid receptor (DOR). In small dorsal root ganglion neurons, only low levels of DORs are present on the cell surface, in contrast to high levels of intracellular DORs mainly associated with vesicles containing calcitonin gene-related peptide (CGRP). Activation of surface DORs caused Ca(2+) release from IP(3)-sensitive stores and Ca(2+) entry, resulting in a slow and long-lasting exocytosis, DOR insertion, and CGRP release. In contrast, membrane depolarization or activation of vanilloid and P2Y(1) receptors induced a rapid DOR insertion. Thus, DOR activation induces a Ca(2+)-dependent insertion of DORs that is coupled to a release of excitatory neuropeptides, suggesting that treatment of inflammatory pain should include blockade of DORs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/P2ry1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0896-6273
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pubmed:author |
pubmed-author:CaiHai-JiangHJ,
pubmed-author:GuanJi-SongJS,
pubmed-author:HökfeltTomasT,
pubmed-author:HeChengC,
pubmed-author:JinShan-XueSX,
pubmed-author:LeeD ADA,
pubmed-author:NingFeng-ShouFS,
pubmed-author:WangLi-HuaLH,
pubmed-author:WangLie-ChenLC,
pubmed-author:XiaoHua-ShengHS,
pubmed-author:XuZhen-ZhongZZ,
pubmed-author:XuZhi-Qing DZQ,
pubmed-author:ZhangChenC,
pubmed-author:ZhangFang-XiongFX,
pubmed-author:ZhangXuX,
pubmed-author:ZhouZhuanZ
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-33
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12526778-Animals,
pubmed-meshheading:12526778-Calcitonin Gene-Related Peptide,
pubmed-meshheading:12526778-Calcium,
pubmed-meshheading:12526778-Calcium Signaling,
pubmed-meshheading:12526778-Cell Membrane,
pubmed-meshheading:12526778-Exocytosis,
pubmed-meshheading:12526778-Fluorescent Antibody Technique,
pubmed-meshheading:12526778-Ganglia, Spinal,
pubmed-meshheading:12526778-Male,
pubmed-meshheading:12526778-Membrane Potentials,
pubmed-meshheading:12526778-Mice,
pubmed-meshheading:12526778-Mice, Inbred C57BL,
pubmed-meshheading:12526778-Microscopy, Electron,
pubmed-meshheading:12526778-Neurons, Afferent,
pubmed-meshheading:12526778-Neuropeptides,
pubmed-meshheading:12526778-Nociceptors,
pubmed-meshheading:12526778-PC12 Cells,
pubmed-meshheading:12526778-Pain,
pubmed-meshheading:12526778-Rats,
pubmed-meshheading:12526778-Receptors, Drug,
pubmed-meshheading:12526778-Receptors, Neurotransmitter,
pubmed-meshheading:12526778-Receptors, Opioid, delta,
pubmed-meshheading:12526778-Receptors, Purinergic P2,
pubmed-meshheading:12526778-Receptors, Purinergic P2Y1,
pubmed-meshheading:12526778-Secretory Vesicles
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pubmed:year |
2003
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pubmed:articleTitle |
Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion.
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pubmed:affiliation |
Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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