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rdf:type |
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lifeskim:mentions |
umls-concept:C0023810,
umls-concept:C0127400,
umls-concept:C0162610,
umls-concept:C0175697,
umls-concept:C0205266,
umls-concept:C0445750,
umls-concept:C1155265,
umls-concept:C1444748,
umls-concept:C1518102,
umls-concept:C1546857,
umls-concept:C2697656
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-15
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pubmed:abstractText |
Compared to mammals, insects, and plants, relatively little is known about innate immune responses in the nematode Caenorhabditis elegans. Previous work showed that Salmonella enterica serovars cause a persistent infection in the C. elegans intestine that triggers gonadal programmed cell death (PCD) and that C. elegans cell death (ced) mutants are more susceptible to Salmonella-mediated killing. To further dissect the role of PCD in C. elegans innate immunity, we identified both C. elegans and S. enterica factors that affect the elicitation of Salmonella-induced PCD. Salmonella-elicited PCD was shown to require the C. elegans homolog of the mammalian p38 mitogen-activated protein kinase (MAPK) encoded by the pmk-1 gene. Inactivation of pmk-1 by RNAi blocked Salmonella-elicited PCD, and epistasis analysis showed that CED-9 lies downstream of PMK-1. Wild-type Salmonella lipopolysaccharide (LPS) was also shown to be required for the elicitation of PCD, as well as for persistence of Salmonella in the C. elegans intestine. However, a presumptive C. elegans TOLL signaling pathway did not appear to be required for the PCD response to Salmonella. These results establish a PMK-1-dependant PCD pathway as a C. elegans innate immune response to Salmonella.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ced-9 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pmk-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Racemases and Epimerases,
http://linkedlifedata.com/resource/pubmed/chemical/RfaL protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/Tol-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/lpcA protein, E coli
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-52
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12526744-Animals,
pubmed-meshheading:12526744-Apoptosis Regulatory Proteins,
pubmed-meshheading:12526744-Bacterial Proteins,
pubmed-meshheading:12526744-Caenorhabditis elegans,
pubmed-meshheading:12526744-Caenorhabditis elegans Proteins,
pubmed-meshheading:12526744-Cell Death,
pubmed-meshheading:12526744-Escherichia coli Proteins,
pubmed-meshheading:12526744-Immune System,
pubmed-meshheading:12526744-Ligases,
pubmed-meshheading:12526744-Lipopolysaccharides,
pubmed-meshheading:12526744-MAP Kinase Signaling System,
pubmed-meshheading:12526744-Membrane Proteins,
pubmed-meshheading:12526744-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:12526744-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12526744-Mutation,
pubmed-meshheading:12526744-Nerve Tissue Proteins,
pubmed-meshheading:12526744-Proto-Oncogene Proteins,
pubmed-meshheading:12526744-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12526744-Racemases and Epimerases,
pubmed-meshheading:12526744-Salmonella enterica
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pubmed:year |
2003
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pubmed:articleTitle |
Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, 02114, Boston, MA, USA. a.aballay@duke.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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