Linked Life Data

12525869

Source:http://linkedlifedata.com/resource/pubmed/id/12525869

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-1-14
pubmed:abstractText
Transplant renal arteriosclerosis (TRA), characterized by concentric neointimal thickening, is one of the major causes of chronic rejection in human kidney transplantation. Endothelin-1 is known to be a powerful vasoconstrictor and a vascular smooth muscle cell mitogen. Previous experimental studies have shown that endothelin-A receptor (ET(A) receptor) is expressed selectively in vascular smooth muscle cells, and is the major mediator of endothelin-1-induced effects. However, ET(A) receptor expression in human renal allografts has not been reported. In this study, we immunohistochemically investigated the expression of ET(A) receptor in relation to the development of TRA, using nine human renal allografts removed due to rejection and ten normal kidneys as controls. In intrarenal arteries of normal kidneys, medial smooth muscle cells showed weak expression of ET(A) receptor. In intrarenal arteries with TRA of human renal allografts, increased expression of ET(A) receptor was found in medial smooth muscle cells, and distinct expression of ET(A) receptor was also detected in smooth muscle cells within the neointima. These results suggest that enhanced expression of ET(A) receptor may induce an increase in the local proliferative and vasoconstrictive effects of endothelin-1 in human renal allografts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1107-3756
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Enhanced expression of endothelin-A receptor in human transplant renal arteriosclerosis.
pubmed:affiliation
Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
pubmed:publicationType
Journal Article