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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-14
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pubmed:abstractText |
Several chemokines have been shown to regulate cellular apoptosis following discrete stimuli. It was previously demonstrated that the CC chemokine CCL1 (I-309) rescues thymic lymphoma cells from apoptosis by unknown mechanisms. The aim of our study was to characterize the role of the CC chemokine receptor 8 (CCR8), the only described receptor for CCL1, in the rescue of murine thymic lymphoma cells and murine thymocytes from dexamethasone (dex)-induced apoptosis. We show here that the CCR8-restricted agonist Kaposi sarcoma-associated herpesvirus-encoded chemokine viral macrophage-inflammatory protein-1 (vMIP-1) rescues thymic lymphoma cells from dex-induced apoptosis, similar to CCL1, and that such rescue is extracellular-regulated kinase-dependent. Although it has been hypothesized that the rescuing effect of CCL1 from apoptosis could be CCR8-mediated, here, we formally demonstrate the role of such receptor as its selective antagonist encoded by the MC148 gene of molluscum contagiosum virus MC148/vMCC-I inhibits v-MIP-1- and CCL1-induced rescue activity. In addition, CCR8 ligands inhibit dex-induced apoptosis of murine thymocytes with potential implications for thymic selection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/MC148 protein, poxvirus molluscum...,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR8,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/vMIP-1 protein, Human herpesvirus 8
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12525579-Animals,
pubmed-meshheading:12525579-Apoptosis,
pubmed-meshheading:12525579-Binding Sites,
pubmed-meshheading:12525579-Calcium Signaling,
pubmed-meshheading:12525579-Chemokine CCL1,
pubmed-meshheading:12525579-Chemokines, CC,
pubmed-meshheading:12525579-Chemotaxis, Leukocyte,
pubmed-meshheading:12525579-Dexamethasone,
pubmed-meshheading:12525579-Female,
pubmed-meshheading:12525579-Humans,
pubmed-meshheading:12525579-Lymphoma, T-Cell,
pubmed-meshheading:12525579-Macrophage Inflammatory Proteins,
pubmed-meshheading:12525579-Mice,
pubmed-meshheading:12525579-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12525579-Receptors, CCR8,
pubmed-meshheading:12525579-Receptors, Chemokine,
pubmed-meshheading:12525579-Signal Transduction,
pubmed-meshheading:12525579-Thymus Gland,
pubmed-meshheading:12525579-Viral Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway.
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pubmed:affiliation |
Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Monti di Creta 104, 00167 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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