12524658

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017785, umls-concept:C0030705, umls-concept:C0332307, umls-concept:C0380315, umls-concept:C0439849, umls-concept:C0542341, umls-concept:C0663193, umls-concept:C1419119, umls-concept:C1511983, umls-concept:C1609982, umls-concept:C2587213
pubmed:issue	1
pubmed:dateCreated	2003-1-13
pubmed:abstractText	Circulating autoantibodies (Ab) to islet autoantigens, glutamic acid decarboxylase (GAD(65)), and tyrosine phosphatase ICA512/IA-2 have been proposed as predictive markers of type 1 diabetes mellitus. To ascertain residual beta-cell function and the clinical relevance for monitoring autoimmunity after clinical manifestation of disease, we studied 63 children at diagnosis of type 1 diabetes (mean SD age 7.5 +/- 4 years) and 91 adolescent patients with type 1 diabetes (age 14.7 +/- 1.6 years) with a mean duration of disease of 7 +/- 3.5) years. Forty-two normal adolescent subjects (age 14.6 +/- 1.8 years) without a family history of diabetes were the control group. Anti-GAD(65) and ICA512/IA-2 Ab were assessed by a quantitative radioimmunoprecipitation assay. The relationship between humoral autoimmunity and clinical parameters was explored. GAD(65) and ICA512/IA-2 Ab were detected in 56% and 63% of newly diagnosed children and the prevalence was not different in relationship to clinical characteristics. Levels of GAD(65) Ab positively correlated with diagnosis age (P <.05). Both Ab were associated with islet cell antibodies (ICA) (P <.05), but one fifth of patients had at least 1 of the 2 Ab and absent ICA. At onset, only age showed a significant relationship to residual C-peptide secretion. Among the cohort of patients with diabetes of short-mid duration, GAD(65) and ICA512/IA-2 Ab were present in 44% and 45% of cases (P >.05 and P <.05 v newly diagnosed children, respectively) and more patients were identified by these Ab (68%) than by ICA alone (34%) (P <.05). In this cohort, levels of ICA512/IA-2 Ab negatively correlated with levels of glycosylated hemoglobin (HbA(1c)) (P <.005) and with daily insulin requirement (P <.05). Moreover, the presence of some residual C-peptide secretion was significantly associated with the presence of ICA512/IA-2 Ab (P <.05). Our findings confirm that positivity for either GAD(65) or ICA512/IA-2 Ab is a highly sensitive marker of type 1 diabetes in the pediatric age group, identifying a group of patients with absent ICA immunofluorescence. The persistence of Ab to islet tyrosine phosphatase possibly represents a marker of better glycemic control and less insulin requirement, indicating residual beta-cell function, thus conferring clinical and prognostic relevance to these Ab, as well as potential usefulness in intervention strategies.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0375267
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies, http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose, http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide, http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase, http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PTPRN protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase..., http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases, http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Like Protein Tyrosine..., http://linkedlifedata.com/resource/pubmed/chemical/glutamate decarboxylase 2
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0026-0495
pubmed:author	pubmed-author:CatalfamoEE, pubmed-author:Cavallo-PerinPP, pubmed-author:CeruttiFF, pubmed-author:PietropaoloS LSL, pubmed-author:RabboneII, pubmed-author:SacchettiCC, pubmed-author:TruccoMM, pubmed-author:ZanoneM MMM
pubmed:copyrightInfo	Copyright 2003, Elsevier Science (USA). All rights reserved.
pubmed:issnType	Print
pubmed:volume	52
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	25-9
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:12524658-Adolescent, pubmed-meshheading:12524658-Autoantibodies, pubmed-meshheading:12524658-Autoantigens, pubmed-meshheading:12524658-Biological Markers, pubmed-meshheading:12524658-Blood Glucose, pubmed-meshheading:12524658-C-Peptide, pubmed-meshheading:12524658-Child, pubmed-meshheading:12524658-Cohort Studies, pubmed-meshheading:12524658-Diabetes Mellitus, Type 1, pubmed-meshheading:12524658-Female, pubmed-meshheading:12524658-Glutamate Decarboxylase, pubmed-meshheading:12524658-Hemoglobin A, Glycosylated, pubmed-meshheading:12524658-Humans, pubmed-meshheading:12524658-Islets of Langerhans, pubmed-meshheading:12524658-Isoenzymes, pubmed-meshheading:12524658-Male, pubmed-meshheading:12524658-Membrane Proteins, pubmed-meshheading:12524658-Protein Tyrosine Phosphatase, Non-Receptor Type 1, pubmed-meshheading:12524658-Protein Tyrosine Phosphatases, pubmed-meshheading:12524658-Radioimmunoassay, pubmed-meshheading:12524658-Receptor-Like Protein Tyrosine Phosphatases, Class 8
pubmed:year	2003
pubmed:articleTitle	Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycemic control in young type 1 diabetic patients.
pubmed:affiliation	Division of Internal Medicine, University of Torino, Torino, Italy.
pubmed:publicationType	Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't