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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-13
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pubmed:abstractText |
Coeliac disease (CD) is an enteropathy mediated by gluten specific T cells which secrete interferon gamma (IFN-gamma) when stimulated by gluten peptides presented by HLA-DQ2 or DQ8 molecules. Residues 62-75 of alpha(2) gliadin have been proposed as the immunodominant epitope in the majority of CD patients. Deamidation by tissue transglutaminase (tTG) of the glutamine (Q) at position 65 to glutamic acid (E) is essential for T cell stimulation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-10383530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-10540324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-10582760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-10684852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-10700238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-10837052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-11001798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-11051363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-11465088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-11592927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-12524389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-7481543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-7520895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-7615276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-7672681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-7907731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-8483498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-8552189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-8717505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-8921967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-9041236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-9472676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-9623982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-9707598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12524402-9721152
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12524402-Adult,
pubmed-meshheading:12524402-Aged,
pubmed-meshheading:12524402-Alanine,
pubmed-meshheading:12524402-Amino Acid Sequence,
pubmed-meshheading:12524402-Celiac Disease,
pubmed-meshheading:12524402-Cell Line,
pubmed-meshheading:12524402-Clone Cells,
pubmed-meshheading:12524402-Cytokines,
pubmed-meshheading:12524402-Down-Regulation,
pubmed-meshheading:12524402-Epitopes,
pubmed-meshheading:12524402-Female,
pubmed-meshheading:12524402-Glutens,
pubmed-meshheading:12524402-Humans,
pubmed-meshheading:12524402-Immunity, Cellular,
pubmed-meshheading:12524402-Interferon-gamma,
pubmed-meshheading:12524402-Intestine, Small,
pubmed-meshheading:12524402-Lymphocyte Activation,
pubmed-meshheading:12524402-Male,
pubmed-meshheading:12524402-Middle Aged,
pubmed-meshheading:12524402-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
Investigation of the putative immunodominant T cell epitopes in coeliac disease.
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pubmed:affiliation |
Gastroenterology Unit, Rayne Institute (KCL), St Thomas' Hospital, London, UK. julia.ellis@kcl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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