| pubmed-article:12524347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12524347 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12524347 | lifeskim:mentions | umls-concept:C0017258 | lld:lifeskim |
| pubmed-article:12524347 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:12524347 | lifeskim:mentions | umls-concept:C1156187 | lld:lifeskim |
| pubmed-article:12524347 | lifeskim:mentions | umls-concept:C1448829 | lld:lifeskim |
| pubmed-article:12524347 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:12524347 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12524347 | pubmed:dateCreated | 2003-1-13 | lld:pubmed |
| pubmed-article:12524347 | pubmed:abstractText | Mutations in the gene for Su(var)3-9 are dominant suppressors of position-effect variegation (PEV). We show that SU(VAR)3-9 is a chromatin-associated protein and identify the large multicopy histone gene cluster (HIS-C) as one of its target loci. The organization of nucleosomes over the entire HIS-C region is altered in Su(var)3-9 mutants and there is a concomitant increase in expression of the histone genes. SU(VAR)3-9 is a histone H3 methyltransferase and, using chromatin immunoprecipitation, we show that SU(VAR)3-9 is present at the HIS-C locus and that the histone H3 at the HIS-C locus is methylated. We propose that SU(VAR)3-9 is involved in packaging HIS-C into a distinct chromatin domain that has some of the characteristics of beta-heterochromatin. We suggest that methylation of histone H3 is important for the chromatin structure at HIS-C. The chromosomal deficiency for the HIS-C is also a suppressor of PEV. In contrast to what might be expected, we show that hemizygosity for the HIS-C locus leads to a substantial increase in the histone transcripts. | lld:pubmed |
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| pubmed-article:12524347 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12524347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12524347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12524347 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12524347 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:12524347 | pubmed:author | pubmed-author:NerSarbjit... | lld:pubmed |
| pubmed-article:12524347 | pubmed:author | pubmed-author:HarringtonMic... | lld:pubmed |
| pubmed-article:12524347 | pubmed:author | pubmed-author:GrigliattiTho... | lld:pubmed |
| pubmed-article:12524347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12524347 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:12524347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12524347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12524347 | pubmed:pagination | 1763-74 | lld:pubmed |
| pubmed-article:12524347 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
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| pubmed-article:12524347 | pubmed:meshHeading | pubmed-meshheading:12524347... | lld:pubmed |
| pubmed-article:12524347 | pubmed:meshHeading | pubmed-meshheading:12524347... | lld:pubmed |
| pubmed-article:12524347 | pubmed:meshHeading | pubmed-meshheading:12524347... | lld:pubmed |
| pubmed-article:12524347 | pubmed:meshHeading | pubmed-meshheading:12524347... | lld:pubmed |
| pubmed-article:12524347 | pubmed:meshHeading | pubmed-meshheading:12524347... | lld:pubmed |
| pubmed-article:12524347 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12524347 | pubmed:articleTitle | A role for the Drosophila SU(VAR)3-9 protein in chromatin organization at the histone gene cluster and in suppression of position-effect variegation. | lld:pubmed |
| pubmed-article:12524347 | pubmed:affiliation | Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. ner@zoology.ubc.ca | lld:pubmed |
| pubmed-article:12524347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12524347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
