Linked Life Data

12524142

Source:http://linkedlifedata.com/resource/pubmed/id/12524142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2003-1-13
pubmed:abstractText
Studies have shown that cocaine alters the function of recombinant 5-HT(3) receptors and that behavioral responses to cocaine are affected by 5-HT(3) receptor ligands. However, the actions of cocaine on brain 5-HT(3) receptors have not been characterized because these receptors are not abundantly expressed in most neuronal populations. We examined the effect of cocaine on 5-HT(3) receptor function in cultured hippocampal neurons from transgenic mice overexpressing the receptor. Cocaine competitively inhibited 5-HT(3) receptors with an IC(50) of approximately 4 microM, indicating that brain 5-HT(3) receptors are important targets for the actions of this commonly abused substance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
459
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Cocaine inhibits 5-HT3 receptor function in neurons from transgenic mice overexpressing the receptor.
pubmed:affiliation
Department of Neurosciences, University of New Mexico Health Sciences Center, Basic Medical Sciences Building, Room 145, Albuquerque, NM 87131-5223, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.