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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1975-11-5
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pubmed:abstractText |
Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r = 6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) -- HL-A (2nd locus)--MLC-Bf---PGM(3). The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0018-7348
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-83
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:125222-Chromosome Mapping,
pubmed-meshheading:125222-Chromosomes, Human, 6-12 and X,
pubmed-meshheading:125222-Complement System Proteins,
pubmed-meshheading:125222-Crossing Over, Genetic,
pubmed-meshheading:125222-Electrophoresis, Starch Gel,
pubmed-meshheading:125222-Female,
pubmed-meshheading:125222-Gene Frequency,
pubmed-meshheading:125222-Genetic Linkage,
pubmed-meshheading:125222-Germany, West,
pubmed-meshheading:125222-HLA Antigens,
pubmed-meshheading:125222-Histocompatibility,
pubmed-meshheading:125222-Histocompatibility Antigens,
pubmed-meshheading:125222-Humans,
pubmed-meshheading:125222-Immunogenetics,
pubmed-meshheading:125222-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:125222-Male,
pubmed-meshheading:125222-Phenotype,
pubmed-meshheading:125222-Phosphoglucomutase,
pubmed-meshheading:125222-Polymorphism, Genetic,
pubmed-meshheading:125222-Properdin,
pubmed-meshheading:125222-Recombination, Genetic
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pubmed:year |
1975
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pubmed:articleTitle |
Linkage group HL-A-MLC-BF (properdin factor B). The site of the Bf locus at the immunogenetic linkage group on chromosome 6.
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pubmed:publicationType |
Journal Article
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