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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5604
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pubmed:dateCreated |
2003-1-10
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pubmed:abstractText |
Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76-deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescein-5-isothiocyanate,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/SLP-76 signal Transducing adaptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Syk kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Xlkd1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/fluorescein isothiocyanate dextran,
http://linkedlifedata.com/resource/pubmed/chemical/prospero-related homeobox 1 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:AbtahianFarhadF,
pubmed-author:FerrariVictor AVA,
pubmed-author:GuerrieroAnastasiaA,
pubmed-author:HuangBinB,
pubmed-author:JacksonDavid GDG,
pubmed-author:KahnMark LML,
pubmed-author:KoretzkyGary AGA,
pubmed-author:LeporeJohn JJJ,
pubmed-author:LowellClifford ACA,
pubmed-author:LuMin-MinMM,
pubmed-author:MocsaiAttilaA,
pubmed-author:MyersErin EEE,
pubmed-author:SebzdaEricE,
pubmed-author:TybulewiczVictorV,
pubmed-author:ZhouRongR
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
299
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-51
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:12522250-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12522250-Animals,
pubmed-meshheading:12522250-Animals, Newborn,
pubmed-meshheading:12522250-Antigens, CD34,
pubmed-meshheading:12522250-Blood Vessels,
pubmed-meshheading:12522250-Bone Marrow Cells,
pubmed-meshheading:12522250-Bone Marrow Transplantation,
pubmed-meshheading:12522250-Dextrans,
pubmed-meshheading:12522250-Endothelium, Lymphatic,
pubmed-meshheading:12522250-Endothelium, Vascular,
pubmed-meshheading:12522250-Enzyme Precursors,
pubmed-meshheading:12522250-Fluorescein-5-isothiocyanate,
pubmed-meshheading:12522250-Glycoproteins,
pubmed-meshheading:12522250-Hemorrhage,
pubmed-meshheading:12522250-Homeodomain Proteins,
pubmed-meshheading:12522250-Intestines,
pubmed-meshheading:12522250-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12522250-Lymphatic System,
pubmed-meshheading:12522250-Mesenteric Arteries,
pubmed-meshheading:12522250-Mesenteric Veins,
pubmed-meshheading:12522250-Mice,
pubmed-meshheading:12522250-Phosphoproteins,
pubmed-meshheading:12522250-Protein-Tyrosine Kinases,
pubmed-meshheading:12522250-Signal Transduction,
pubmed-meshheading:12522250-Stem Cells,
pubmed-meshheading:12522250-Tumor Suppressor Proteins,
pubmed-meshheading:12522250-Vascular Endothelial Growth Factor Receptor-3,
pubmed-meshheading:12522250-Veins
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pubmed:year |
2003
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pubmed:articleTitle |
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
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pubmed:affiliation |
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article
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