Source:http://linkedlifedata.com/resource/pubmed/id/12519860
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-1-9
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| pubmed:abstractText |
The 112/121 haplotype combination defined by the UCSNP-43, -19, and -63 alleles in the calpain-10 gene is associated with type 2 diabetes in Mexican Americans. To determine whether this genetic variation constitutes risk of type 2 diabetes in Japanese, we investigated its frequency in 177 patients with type 2 diabetes and 172 controls. Though this variation occurs in Japanese more frequently than in Mexican Americans, there is no significant difference in frequency between diabetic (29.9%) and control (31.9%) subjects. We also screened all exons and the putative promoter of the calpain-10 gene for mutations in 96 of the genotyped patients, resulting in the identification of 7 coding variants, including 3 missense mutations and 5 nucleotide alterations in the promoter. However, their frequencies all are similar in patients and controls, suggesting that these genetic variations are not a major factor in the occurrence of type 2 diabetes in Japanese, although they could yet be associated with various phenotypes of the disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
88
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
244-7
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:12519860-Aged,
pubmed-meshheading:12519860-Asian Continental Ancestry Group,
pubmed-meshheading:12519860-Calpain,
pubmed-meshheading:12519860-Diabetes Mellitus, Type 2,
pubmed-meshheading:12519860-Female,
pubmed-meshheading:12519860-Gene Frequency,
pubmed-meshheading:12519860-Genetic Predisposition to Disease,
pubmed-meshheading:12519860-Genetic Testing,
pubmed-meshheading:12519860-Genetic Variation,
pubmed-meshheading:12519860-Glucose Clamp Technique,
pubmed-meshheading:12519860-Haplotypes,
pubmed-meshheading:12519860-Humans,
pubmed-meshheading:12519860-Japan,
pubmed-meshheading:12519860-Male,
pubmed-meshheading:12519860-Mexican Americans,
pubmed-meshheading:12519860-Middle Aged,
pubmed-meshheading:12519860-Polymorphism, Genetic,
pubmed-meshheading:12519860-Promoter Regions, Genetic
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| pubmed:year |
2003
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| pubmed:articleTitle |
Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese.
|
| pubmed:affiliation |
Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan. yhorika@showa.gunma-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|