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rdf:type |
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lifeskim:mentions |
umls-concept:C0020846,
umls-concept:C0021368,
umls-concept:C0039194,
umls-concept:C0205276,
umls-concept:C0205373,
umls-concept:C0458827,
umls-concept:C0700624,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1880177,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-9
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pubmed:abstractText |
Allergic airway inflammation induced in mice is T-cell dependent and recruitment of eosinophils to airspaces requires both alphabeta and gammadelta T cells. From previous studies it is evident that alphabeta T cells are essential for the allergic T helper type 2 (Th2)-like response, while the mechanistic contribution of gammadelta T cells is still unclear. In this study, we have investigated the role of gammadelta T cells in allergic airway eosinophilia induced by ovalbumin hypersensitivity. By comparing the responsiveness to sensitizing allergen of wild-type mice with that of T-cell receptor gammadelta knockout mice (TCRgammadelta KO) we demonstrated that mice lacking gammadelta T cells are defective in the systemic ovalbumin-specific immunoglobulin E (IgE) response. Furthermore, after aerosol challenge with allergen, gammadelta T-cell deficient mice exhibited a significantly decreased migration of B cells and natural killer cells to airways and reduced levels of allergen-specific IgG and IgA in bronchoalveolar lavage fluid. The role for B cells in the airway inflammation was indicated by the impaired ability of mice lacking functional B cells to evoke an eosinophilic response. The diminished eosinophilia in TCRgammadelta KO mice could not be explained by a defective Th2 activation since these mice displayed a normal IgG response in serum and an unaffected IG2b/IgG1 ratio in airways. Analysis of immunoregulatory cytokines in isolated lung tissue, thoracic lymph nodes and spleen further supported the notion that these mice are able to evoke a sufficient activation of T helper cells and that gammadelta T cells are not required for maintaining the Th2 profile. These results indicate that gammadelta T cells contribute to allergic airway inflammation by pathways separate from classical Th2 immune activation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10030835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10340953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10358759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10502558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10502818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10606934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10657943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10844534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10854227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-10960670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-11083820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-11145709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1371472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1386297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1533291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1634244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1692153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1826649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-1826884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2113432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2141568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2148640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2148643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2455455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2461518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2527159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2564416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-2968521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-3107127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-3971600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-7703309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-7813110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-7916481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-7923890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-8011284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-8047141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-8207227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-8617871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-8690925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-8849370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9037056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9120394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9218604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9227326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9465484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9491232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9596580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9754552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12519308-9927517
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-108
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12519308-Animals,
pubmed-meshheading:12519308-Mice,
pubmed-meshheading:12519308-Lung,
pubmed-meshheading:12519308-Spleen,
pubmed-meshheading:12519308-Lymph Nodes,
pubmed-meshheading:12519308-Pulmonary Eosinophilia,
pubmed-meshheading:12519308-Respiratory Hypersensitivity,
pubmed-meshheading:12519308-Immunoglobulin G,
pubmed-meshheading:12519308-Immunoglobulin E,
pubmed-meshheading:12519308-Mice, Inbred C57BL,
pubmed-meshheading:12519308-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:12519308-B-Lymphocytes,
pubmed-meshheading:12519308-T-Lymphocyte Subsets,
pubmed-meshheading:12519308-Receptors, Antigen, T-Cell, gamma-delta
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