Linked Life Data

12518804

Source:http://linkedlifedata.com/resource/pubmed/id/12518804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-1-9
pubmed:abstractText
pH-sensitive hydrogels are suitable candidates for oral delivery of therapeutic peptides and proteins, due to their ability to respond to environmental pH changes. New pH-sensitive glycopolymers have been developed by free-radical photopolymerization of methacrylic acid and 2-methacryloxyethyl glucoside, using tetra(ethylene glycol) dimethacrylate as a cross-linking agent. To determine the suitability of these hydrogels as carriers for oral drug delivery devices, their swelling behavior was investigated as a function of the pH and copolymer compositions, and various structural parameters such as the number-average molecular weight between cross-links, Mc, the mesh size, xi, and the cross-linking density, rho(x), were calculated. The transition between the swollen and the collapsed states of these hydrogels was at a pH of 5. The swelling ratios of the hydrogels increased at pH values above 5. The mesh sizes of the hydrogels were between 18 and 35 A in the collapsed state (at pH 2.2) and between 70 and 111 A in the swollen state (at pH 7.0). Finally, as the cross-linking ratio of the copolymer increased, the swelling ratio of the hydrogels decreased at both pH 2.2 and 7.0.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-5063
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1271-81
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems.
pubmed:affiliation
Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.