Source:http://linkedlifedata.com/resource/pubmed/id/12518166
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| Predicate | Object |
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| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-1-8
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| pubmed:abstractText |
Gammadelta T-cells participate in the immune response to infections and in autoimmunity by recognizing bacteria-derived and autologous antigens. The goal of this study was to evaluate the involvement of gammadelta T-cells in Behçet's disease (BD). Gammadelta T-cells in the peripheral-blood mononuclear cells (PBMCs) of Israeli patients with definite BD (n = 23), normal controls (n = 16), and patients with familial Mediterrranean fever (FMF; n = 20) were evaluated by means of flow cytometry. The responses of patient and control gammadelta T-cells to medium conditioned by microorganisms cultured from an oral ulcer of a patient with active BD were compared. The proportions of CD3(+) and CD8(+) cells in the PBMCs were not significantly different between groups. In contrast, gammadelta-T-cells accounted for 7.01% +/- 4.42% of the PBMCs in BD compared with 3.56% +/- 3.45% in FMF (P < .005) and 3.7% +/- 3.15% in normal individuals (P < .009). Their numbers were significantly higher during active disease than in remission (9.45% +/- 5.08% versus 2.27% +/- 3.3%; P < .009). The number of T-cell-receptor gammadelta(+) and Vdelta2(+) cells of BD patients, but not of controls, increased after 96 hours of culture in medium containing supernatant of microorganisms cultured from an oral ulcer in a patient with BD relative to their proportions in control medium: 58.2% vs 13.9% (P < .05) and 28% vs 9% (P < .04), respectively, of the cultured T-cells (n = 4).gammadelta T-cells are expanded in BD PBMCs during active disease. An exaggerated proliferative response to products released by microorganisms present in oral ulcers may play a role in this phenomenon.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0022-2143
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
141
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
33-40
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12518166-Adult,
pubmed-meshheading:12518166-Antigens, Bacterial,
pubmed-meshheading:12518166-Antigens, CD3,
pubmed-meshheading:12518166-Antigens, CD8,
pubmed-meshheading:12518166-Bacteria,
pubmed-meshheading:12518166-Behcet Syndrome,
pubmed-meshheading:12518166-Cells, Cultured,
pubmed-meshheading:12518166-Culture Media, Conditioned,
pubmed-meshheading:12518166-Female,
pubmed-meshheading:12518166-Flow Cytometry,
pubmed-meshheading:12518166-Humans,
pubmed-meshheading:12518166-Lymphocyte Activation,
pubmed-meshheading:12518166-Lymphocyte Count,
pubmed-meshheading:12518166-Lymphocyte Subsets,
pubmed-meshheading:12518166-Male,
pubmed-meshheading:12518166-Middle Aged,
pubmed-meshheading:12518166-Oral Ulcer,
pubmed-meshheading:12518166-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12518166-T-Lymphocytes
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| pubmed:year |
2003
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| pubmed:articleTitle |
Expansion of gammadelta T-cells in Behçet's disease: role of disease activity and microbial flora in oral ulcers.
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| pubmed:affiliation |
Department of Medicine, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Hashomer, Israel. ibank@post.tau.ac.il
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| pubmed:publicationType |
Journal Article
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