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pubmed-article:12512026pubmed:abstractTextThe human multidrug resistance 1 (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics. The finding that mdr1a knockout mice develop a form of colitis that is similar to ulcerative colitis, which can be prevented by antibiotics, indicates a barrier function for P-glycoprotein against the invasion of bacteria or toxins. Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.lld:pubmed
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pubmed-article:12512026pubmed:articleTitleAssociation between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.lld:pubmed
pubmed-article:12512026pubmed:affiliationDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany. matthias.schwab@kp-stuttgart.delld:pubmed
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