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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-1-3
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pubmed:abstractText |
The human multidrug resistance 1 (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics. The finding that mdr1a knockout mice develop a form of colitis that is similar to ulcerative colitis, which can be prevented by antibiotics, indicates a barrier function for P-glycoprotein against the invasion of bacteria or toxins. Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:BrinkmannUlrichU,
pubmed-author:CascorbiIngolfI,
pubmed-author:EichelbaumMichelM,
pubmed-author:FrommMartin FMF,
pubmed-author:GregorMichaelM,
pubmed-author:HerfarthHansH,
pubmed-author:KaskasBerndB,
pubmed-author:MarxClaudiaC,
pubmed-author:MetzlerJoergJ,
pubmed-author:RootsIvarI,
pubmed-author:SchaeffelerElkeE,
pubmed-author:SchoelmerichJuergenJ,
pubmed-author:SchwabMatthiasM,
pubmed-author:StangeEduardE,
pubmed-author:WalkerSiegfriedS,
pubmed-author:ZangerUlrich MUM
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12512026-Adolescent,
pubmed-meshheading:12512026-Adult,
pubmed-meshheading:12512026-Aged,
pubmed-meshheading:12512026-Alleles,
pubmed-meshheading:12512026-Case-Control Studies,
pubmed-meshheading:12512026-Colitis, Ulcerative,
pubmed-meshheading:12512026-Control Groups,
pubmed-meshheading:12512026-Crohn Disease,
pubmed-meshheading:12512026-Female,
pubmed-meshheading:12512026-Gene Frequency,
pubmed-meshheading:12512026-Genes, MDR,
pubmed-meshheading:12512026-Genetic Predisposition to Disease,
pubmed-meshheading:12512026-Genotype,
pubmed-meshheading:12512026-Humans,
pubmed-meshheading:12512026-Male,
pubmed-meshheading:12512026-Middle Aged,
pubmed-meshheading:12512026-Polymorphism, Genetic
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pubmed:year |
2003
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pubmed:articleTitle |
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.
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pubmed:affiliation |
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany. matthias.schwab@kp-stuttgart.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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