| pubmed-article:12510860 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C0031001 | lld:lifeskim |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C0007799 | lld:lifeskim |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C0014295 | lld:lifeskim |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C0034929 | lld:lifeskim |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12510860 | lifeskim:mentions | umls-concept:C0066808 | lld:lifeskim |
| pubmed-article:12510860 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:12510860 | pubmed:dateCreated | 2003-1-3 | lld:pubmed |
| pubmed-article:12510860 | pubmed:abstractText | Opioids administered by intracerebroventricular injections produce analgesic responses in rats. The present study was undertaken to investigate the effects of a highly selective mu-opioid receptor ligand morphiceptin on trigemino-hypoglossal reflex in rats. The analgesic effect of morphiceptin was compared with another opioid peptide, Met-enkephalin. With the experimental settings used in this study, we have demonstrated that both morphiceptin and Met-enkephalin show significant dose-dependent analgesic effects after i.c.v. administration in rats as assayed by trigemino-hypoglossal reflex test. The antinociceptive response to Met-enkephalin was short lasting and was observed 10 to 15 min after i.c.v. perfusion. Morphiceptin had a relatively longer duration of antinociceptive action, the effect was observed 20-50 min after i.c.v. perfusion. Neither morphiceptin nor Met-enkephalin produced antinociception after peripheral injections. The results of the present study indicate that both tested peptides act at mu-opioid receptors situated in the central nervous system. They also suggest that mu-opioid receptors present in the central nervous system are an important element of the trigemino-hypoglossal reflex arc. For that reason selective mu-opioid receptor ligands, like morphiceptin, inhibit the reflex more significantly. | lld:pubmed |
| pubmed-article:12510860 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12510860 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12510860 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12510860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12510860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12510860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12510860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12510860 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12510860 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12510860 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12510860 | pubmed:issn | 0867-5910 | lld:pubmed |
| pubmed-article:12510860 | pubmed:author | pubmed-author:JaneckaAA | lld:pubmed |
| pubmed-article:12510860 | pubmed:author | pubmed-author:ZubrzyckaMM | lld:pubmed |
| pubmed-article:12510860 | pubmed:author | pubmed-author:FichnaJJ | lld:pubmed |
| pubmed-article:12510860 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12510860 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:12510860 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12510860 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12510860 | pubmed:pagination | 741-50 | lld:pubmed |
| pubmed-article:12510860 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
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| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:meshHeading | pubmed-meshheading:12510860... | lld:pubmed |
| pubmed-article:12510860 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12510860 | pubmed:articleTitle | Effect of cerebral ventricles perfusion with morphiceptin and Met-enkephalin on trigemino-hypoglossal reflex in rats. | lld:pubmed |
| pubmed-article:12510860 | pubmed:affiliation | Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland. | lld:pubmed |
| pubmed-article:12510860 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12510860 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12510860 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
