Source:http://linkedlifedata.com/resource/pubmed/id/12510860
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 2
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| pubmed:dateCreated |
2003-1-3
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| pubmed:abstractText |
Opioids administered by intracerebroventricular injections produce analgesic responses in rats. The present study was undertaken to investigate the effects of a highly selective mu-opioid receptor ligand morphiceptin on trigemino-hypoglossal reflex in rats. The analgesic effect of morphiceptin was compared with another opioid peptide, Met-enkephalin. With the experimental settings used in this study, we have demonstrated that both morphiceptin and Met-enkephalin show significant dose-dependent analgesic effects after i.c.v. administration in rats as assayed by trigemino-hypoglossal reflex test. The antinociceptive response to Met-enkephalin was short lasting and was observed 10 to 15 min after i.c.v. perfusion. Morphiceptin had a relatively longer duration of antinociceptive action, the effect was observed 20-50 min after i.c.v. perfusion. Neither morphiceptin nor Met-enkephalin produced antinociception after peripheral injections. The results of the present study indicate that both tested peptides act at mu-opioid receptors situated in the central nervous system. They also suggest that mu-opioid receptors present in the central nervous system are an important element of the trigemino-hypoglossal reflex arc. For that reason selective mu-opioid receptor ligands, like morphiceptin, inhibit the reflex more significantly.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/morphiceptin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0867-5910
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
53
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
741-50
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12510860-Analgesics,
pubmed-meshheading:12510860-Animals,
pubmed-meshheading:12510860-Dental Pulp,
pubmed-meshheading:12510860-Dose-Response Relationship, Drug,
pubmed-meshheading:12510860-Electric Stimulation,
pubmed-meshheading:12510860-Endorphins,
pubmed-meshheading:12510860-Enkephalin, Methionine,
pubmed-meshheading:12510860-Hypoglossal Nerve,
pubmed-meshheading:12510860-Injections, Intraperitoneal,
pubmed-meshheading:12510860-Injections, Intravenous,
pubmed-meshheading:12510860-Injections, Intraventricular,
pubmed-meshheading:12510860-Male,
pubmed-meshheading:12510860-Pain Measurement,
pubmed-meshheading:12510860-Rats,
pubmed-meshheading:12510860-Rats, Wistar,
pubmed-meshheading:12510860-Receptors, Opioid, mu,
pubmed-meshheading:12510860-Reflex,
pubmed-meshheading:12510860-Tongue,
pubmed-meshheading:12510860-Trigeminal Nerve
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| pubmed:year |
2002
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| pubmed:articleTitle |
Effect of cerebral ventricles perfusion with morphiceptin and Met-enkephalin on trigemino-hypoglossal reflex in rats.
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| pubmed:affiliation |
Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|