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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-1-1
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pubmed:abstractText |
Inversion(16) is one of the most frequent chromosomal translocations found in acute myeloid leukemia (AML), occurring in over 8% of AML cases. This translocation results in a protein product that fuses the first 165 amino acids of core binding factor beta to the coiled-coil region of a smooth muscle myosin heavy chain (CBFbeta/SMMHC). CBFbeta interacts with AML1 to form a heterodimer that binds DNA; this interaction increases the affinity of AML1 for DNA. The CBFbeta/SMMHC fusion protein cooperates with AML1 to repress the transcription of AML1-regulated genes. We show that CBFbeta/SMMHC contains a repression domain in the C-terminal 163 amino acids of the SMMHC region that is required for inv(16)-mediated transcriptional repression. This minimal repression domain is sufficient for the association of CBFbeta/SMMHC with the mSin3A corepressor. In addition, the inv(16) fusion protein specifically associates with histone deacetylase 8 (HDAC8). inv(16)-mediated repression is sensitive to HDAC inhibitors. We propose a model whereby the inv(16) fusion protein associates with AML1 to convert AML1 into a constitutive transcriptional repressor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10049357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10233871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10404215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10490596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10508507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10536006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10617663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10655483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10825229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-10984496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-11001911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-11533236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-11561155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-11956074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-12091906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-12417730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-1321401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-1384663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-1391946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-1409722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-2070080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-2762147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-3026737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-7605990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-7662963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-7761424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-7774816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-7969146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8035830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8180380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8351518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8386878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8545124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8565077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8622955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8704203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8818654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-8929537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9047366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9150134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9256429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9315100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9353180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9462740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9486654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9486655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9566865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9632809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9724795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9819404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9819405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12509458-9819429
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HDAC8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Runx1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/SIN3 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/SIN3A transcription factor,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smooth Muscle Myosins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/inv(16) fusion protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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