Linked Life Data

12508678

Source:http://linkedlifedata.com/resource/pubmed/id/12508678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-1-1
pubmed:abstractText
Solid-phase synthesis of three linear peptides overlapping the major immunodominant epitope of HDAg, which located within amino acid (aa) segment 53-108, and peptide aa 167-179 was carried out. The structure of the peptides corresponded to the sequences of isolates HDV type I. Their antigen reactivity was studied by indirect enzyme immunoassay with sera from patients with hepatitis D and from asymptomatic carriers of anti-delta antibodies. Two B-epitopes located within aa 53-80 and 71-93 appeared to be the most immnunoreactive. The use of these peptides in ELISA allowed anti-delta IGg antibodies to be detected with 95% confidence in serum of patients with hepatitis D and with 87% confidence in serum of asymptomatic carriers of anti-delta antibodies. Analysis of obtained data showed that these peptides can be used in new diagnostic anti-HDV tests.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-4088
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Test for specific antibodies to virus hepatitis delta based on synthetic peptides].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract