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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-1-1
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pubmed:abstractText |
Histone deacetylation is associated with transcriptional activation controlled by DNA methylation. It is important to investigate changes of tumor cells treated with agent through two kinds of mechanisms. This study was designed to investigate the synergic effect of histone deacetylase inhibitor, sodium phenylbutyrate(SPB), and demethylating agent, 5-Aza-2'-deoxycytidine(5-Aza-CdR), on cell growth and explore the possibility of re-expression of the hypermethylated and silenced p16 gene in the myeloma cell line U266.
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5,
http://linkedlifedata.com/resource/pubmed/chemical/Azacitidine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylbutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/decitabine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1000-467X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1057-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12508642-Annexin A5,
pubmed-meshheading:12508642-Apoptosis,
pubmed-meshheading:12508642-Azacitidine,
pubmed-meshheading:12508642-Blotting, Western,
pubmed-meshheading:12508642-Cell Cycle,
pubmed-meshheading:12508642-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:12508642-DNA, Neoplasm,
pubmed-meshheading:12508642-DNA Modification Methylases,
pubmed-meshheading:12508642-Drug Synergism,
pubmed-meshheading:12508642-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12508642-Histone Deacetylase Inhibitors,
pubmed-meshheading:12508642-Humans,
pubmed-meshheading:12508642-Multiple Myeloma,
pubmed-meshheading:12508642-Phenylbutyrates,
pubmed-meshheading:12508642-RNA, Messenger,
pubmed-meshheading:12508642-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12508642-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
[Apoptosis and re-expression of p16 gene in the myeloma cell line U266 induced by synergy of histone deacetylase inhibitor and demethylating agent].
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pubmed:affiliation |
Department of Hematology, 2. Central Lab, First Hospital, Peking University, Beijing 100034, P. R. China.
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pubmed:publicationType |
Journal Article,
English Abstract
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