Linked Life Data

1250848

Source:http://linkedlifedata.com/resource/pubmed/id/1250848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1976-4-9
pubmed:abstractText
Angiotensin I (A-I) and angiotensin II (A-II) produced dose-dependent increases in isometric tension in isolated strips of uterine smooth muscle prepared from ovariectomized golden hamsters treated with estrogen. Responses to A-II were consistent with receptor--occupancy theory of agonist--receptor interactions. Inhibition of angiotensin-converting enzyme virtually abolished responses to A-I but not those to A-II. Blockade of A-II receptors inhibited responses to both A-I and A-II. Cholinergic or alpha-adrenergic blockade did not alter uterine responses to either A-I or A-II. These findings suggest that contractile responses elicited in the isolated uterus of the hamster are due to its local conversion to A-II and subsequent interactions with specific A-II receptors. Such conversion occurs at least to the extent of 14 to 27 %.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-11
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Contractile responses to angiotensin I and angiotensin II in hamster uterine smooth muscle.
pubmed:publicationType
Journal Article, In Vitro