| pubmed-article:12508147 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C1522653 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12508147 | lifeskim:mentions | umls-concept:C1319198 | lld:lifeskim |
| pubmed-article:12508147 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12508147 | pubmed:dateCreated | 2002-12-31 | lld:pubmed |
| pubmed-article:12508147 | pubmed:abstractText | CXC chemokines are major chemoattractants for pulmonary polymorphonuclear leukocyte (PMNL) recruitment. To study the effects of interferon (IFN)-gamma on the pulmonary chemokine response to lipopolysaccharide (LPS) challenge, rats were treated with intratracheal IFN-gamma (1x10(5) U/rat) 24 h before an intratracheal LPS (100 microg/rat) challenge. Intratracheal LPS caused significant increases in both cytokine-induced neutrophil chemoattractant (CINC) and macrophage inflammatory protein-2 in bronchoalveolar lavage (BAL) fluid and pulmonary PMNL recruitment. IFN-gamma enhanced these responses. IFN-gamma also increased LPS-induced tumor necrosis factor (TNF)-alpha in BAL fluid. LPS-induced TNF-alpha and CINC mRNA expression in alveolar macrophages was increased by IFN-gamma. CD11b/c and CD18 expression on circulating PMNLs was not affected by IFN-gamma, nor was the chemotaxis of these cells. IFN-gamma increases the pulmonary CXC chemokine response, which may serve as one mechanism underlying enhanced PMNL delivery into the lung. | lld:pubmed |
| pubmed-article:12508147 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12508147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12508147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12508147 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12508147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12508147 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12508147 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:12508147 | pubmed:author | pubmed-author:ZhangPingP | lld:pubmed |
| pubmed-article:12508147 | pubmed:author | pubmed-author:BagbyGregory... | lld:pubmed |
| pubmed-article:12508147 | pubmed:author | pubmed-author:SummerWarren... | lld:pubmed |
| pubmed-article:12508147 | pubmed:author | pubmed-author:NelsonSteveS | lld:pubmed |
| pubmed-article:12508147 | pubmed:author | pubmed-author:QuintonLee... | lld:pubmed |
| pubmed-article:12508147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12508147 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12508147 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:12508147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12508147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12508147 | pubmed:pagination | 62-9 | lld:pubmed |
| pubmed-article:12508147 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12508147 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12508147 | pubmed:articleTitle | Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge. | lld:pubmed |
| pubmed-article:12508147 | pubmed:affiliation | Department of Medicine, Section of Pulmonary/Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA. | lld:pubmed |
| pubmed-article:12508147 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12508147 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12508147 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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