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rdf:type |
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lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0023810,
umls-concept:C0282553,
umls-concept:C0805586,
umls-concept:C0871261,
umls-concept:C1319198,
umls-concept:C1522653,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2709248,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-31
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pubmed:abstractText |
CXC chemokines are major chemoattractants for pulmonary polymorphonuclear leukocyte (PMNL) recruitment. To study the effects of interferon (IFN)-gamma on the pulmonary chemokine response to lipopolysaccharide (LPS) challenge, rats were treated with intratracheal IFN-gamma (1x10(5) U/rat) 24 h before an intratracheal LPS (100 microg/rat) challenge. Intratracheal LPS caused significant increases in both cytokine-induced neutrophil chemoattractant (CINC) and macrophage inflammatory protein-2 in bronchoalveolar lavage (BAL) fluid and pulmonary PMNL recruitment. IFN-gamma enhanced these responses. IFN-gamma also increased LPS-induced tumor necrosis factor (TNF)-alpha in BAL fluid. LPS-induced TNF-alpha and CINC mRNA expression in alveolar macrophages was increased by IFN-gamma. CD11b/c and CD18 expression on circulating PMNLs was not affected by IFN-gamma, nor was the chemotaxis of these cells. IFN-gamma increases the pulmonary CXC chemokine response, which may serve as one mechanism underlying enhanced PMNL delivery into the lung.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Monokines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
62-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12508147-Animals,
pubmed-meshheading:12508147-Antigens, CD18,
pubmed-meshheading:12508147-Chemokine CXCL2,
pubmed-meshheading:12508147-Chemokines,
pubmed-meshheading:12508147-Chemokines, CXC,
pubmed-meshheading:12508147-Chemotactic Factors,
pubmed-meshheading:12508147-Injections, Spinal,
pubmed-meshheading:12508147-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12508147-Interferon-gamma,
pubmed-meshheading:12508147-Lipopolysaccharides,
pubmed-meshheading:12508147-Lung,
pubmed-meshheading:12508147-Male,
pubmed-meshheading:12508147-Monokines,
pubmed-meshheading:12508147-Neutrophils,
pubmed-meshheading:12508147-RNA, Messenger,
pubmed-meshheading:12508147-Rats,
pubmed-meshheading:12508147-Rats, Sprague-Dawley,
pubmed-meshheading:12508147-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge.
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pubmed:affiliation |
Department of Medicine, Section of Pulmonary/Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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