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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-31
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pubmed:abstractText |
Estrogen-mediated cholestasis is an important clinical entity, but its molecular pathophysiology is still not fully understood. Impaired sodium-dependent uptake of bile acids has been associated with diminished expression of a basolateral Na(+)/bile acid cotransporter (Ntcp), whereas sodium-independent uptake is maintained despite a down-regulation of the organic anion transporter Oatp1. Thus, expression of the two other rat Oatps (Oatps2 and -4) was determined in estrogen-induced cholestasis. In addition, known transactivators of Oatp2 and Ntcp were studied to further characterize transcriptional regulation of these transporter genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
1609
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12507762-Animals,
pubmed-meshheading:12507762-Base Sequence,
pubmed-meshheading:12507762-Basement Membrane,
pubmed-meshheading:12507762-Blotting, Northern,
pubmed-meshheading:12507762-Blotting, Western,
pubmed-meshheading:12507762-Cholestasis,
pubmed-meshheading:12507762-DNA Primers,
pubmed-meshheading:12507762-Ethinyl Estradiol,
pubmed-meshheading:12507762-Male,
pubmed-meshheading:12507762-Organic Anion Transporters,
pubmed-meshheading:12507762-Protein Binding,
pubmed-meshheading:12507762-RNA, Messenger,
pubmed-meshheading:12507762-Rats,
pubmed-meshheading:12507762-Rats, Sprague-Dawley,
pubmed-meshheading:12507762-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat.
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pubmed:affiliation |
Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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