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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-30
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pubmed:abstractText |
Age-related macular degeneration (ARMD) is characterized by progressive thickening and accumulation of various lipid-rich extracellular matrix (ECM) deposits under the retinal pigment epithelium (RPE). ECM dysregulation probably contributes to the pathologic course of ARMD. By activating estrogen receptors (ERs), estrogens regulate the expression of genes relevant in the turnover of ECM, among them matrix metalloproteinase (MMP)-2. Estrogen deficiency may predispose to dysregulated synthesis and degradation of ECM, leading to accumulation of collagens and other proteins between the RPE and its basement membrane. The purposes in the current study were to confirm the expression of ERs in human RPE, to elucidate whether these ERs are functional, and to test whether 17beta-estradiol (E(2)) regulates expression of ERs and MMP-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proline,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocarbamates,
http://linkedlifedata.com/resource/pubmed/chemical/fulvestrant,
http://linkedlifedata.com/resource/pubmed/chemical/prolinedithiocarbamate
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12506055-Aged,
pubmed-meshheading:12506055-Aged, 80 and over,
pubmed-meshheading:12506055-Blotting, Western,
pubmed-meshheading:12506055-Cell Culture Techniques,
pubmed-meshheading:12506055-Estradiol,
pubmed-meshheading:12506055-Estrogen Antagonists,
pubmed-meshheading:12506055-Estrogen Receptor alpha,
pubmed-meshheading:12506055-Estrogen Receptor beta,
pubmed-meshheading:12506055-Female,
pubmed-meshheading:12506055-Gene Expression Regulation,
pubmed-meshheading:12506055-Humans,
pubmed-meshheading:12506055-Male,
pubmed-meshheading:12506055-Matrix Metalloproteinase 2,
pubmed-meshheading:12506055-Middle Aged,
pubmed-meshheading:12506055-NF-kappa B,
pubmed-meshheading:12506055-Pigment Epithelium of Eye,
pubmed-meshheading:12506055-Proline,
pubmed-meshheading:12506055-RNA, Messenger,
pubmed-meshheading:12506055-Receptors, Estrogen,
pubmed-meshheading:12506055-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12506055-Thiocarbamates,
pubmed-meshheading:12506055-Transfection
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pubmed:year |
2003
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pubmed:articleTitle |
Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.
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pubmed:affiliation |
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, USA.
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pubmed:publicationType |
Journal Article
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