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rdf:type |
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lifeskim:mentions |
umls-concept:C0006141,
umls-concept:C0009015,
umls-concept:C0014597,
umls-concept:C0015576,
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0680022,
umls-concept:C0929301,
umls-concept:C1333336,
umls-concept:C1336776,
umls-concept:C1425716,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2002-12-30
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pubmed:databankReference |
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pubmed:abstractText |
The CITED family proteins bind to CBP/p300 transcriptional integrators through their conserved C-terminal acidic domain and function as coactivators. The 21-kDa mouse Cited4 protein, a novel member of the CITED family, interacted with CBP/p300 as well as isoforms of the TFAP2 transcription factor, coactivating TFAP2-dependent transcription. The cited4 gene consisted of only a single exon located on chromosome 4 at 56.5-56.8 cM flanked by marker genes kcnq4 and scml1. Expression of Cited4 protein was strong and selective in embryonic hematopoietic tissues and endothelial cells. In adult animals, Cited4 showed strong milk cycle-dependent induction in pregnant and lactating mammary epithelial cells. Strong induction of Cited4 expression was also observed in SCp2 mouse mammary epithelial cells during their prolactin-dependent in vitro differentiation. These results implied possible roles for Cited4 in regulation of gene expression during development and differentiation of blood cells, endothelial cells, and mammary epithelial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/E1A-Associated p300 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Ep300 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0888-7543
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pubmed:author |
pubmed-author:BhattacharyaShoumoS,
pubmed-author:BragançaJoséJ,
pubmed-author:CoserKathryn RKR,
pubmed-author:DunwoodieSally LSL,
pubmed-author:HurJingyungJ,
pubmed-author:IsselbacherKurt JKJ,
pubmed-author:ShiodaToshiT,
pubmed-author:SwinglerTraceyT,
pubmed-author:TakedatsuHirokoH,
pubmed-author:WithingtonSarah LSL,
pubmed-author:YahataTetsuroT
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
601-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12504852-Amino Acid Sequence,
pubmed-meshheading:12504852-Animals,
pubmed-meshheading:12504852-Base Sequence,
pubmed-meshheading:12504852-Blotting, Northern,
pubmed-meshheading:12504852-COS Cells,
pubmed-meshheading:12504852-Cloning, Molecular,
pubmed-meshheading:12504852-DNA,
pubmed-meshheading:12504852-DNA, Complementary,
pubmed-meshheading:12504852-E1A-Associated p300 Protein,
pubmed-meshheading:12504852-Embryo, Mammalian,
pubmed-meshheading:12504852-Epithelial Cells,
pubmed-meshheading:12504852-Exons,
pubmed-meshheading:12504852-Female,
pubmed-meshheading:12504852-Gene Expression,
pubmed-meshheading:12504852-Gene Expression Regulation, Developmental,
pubmed-meshheading:12504852-Genes,
pubmed-meshheading:12504852-In Situ Hybridization,
pubmed-meshheading:12504852-Introns,
pubmed-meshheading:12504852-Male,
pubmed-meshheading:12504852-Mammary Glands, Animal,
pubmed-meshheading:12504852-Mice,
pubmed-meshheading:12504852-Molecular Sequence Data,
pubmed-meshheading:12504852-Nuclear Proteins,
pubmed-meshheading:12504852-Promoter Regions, Genetic,
pubmed-meshheading:12504852-Protein Binding,
pubmed-meshheading:12504852-RNA, Messenger,
pubmed-meshheading:12504852-Sequence Alignment,
pubmed-meshheading:12504852-Sequence Analysis, DNA,
pubmed-meshheading:12504852-Sequence Homology, Amino Acid,
pubmed-meshheading:12504852-Sequence Homology, Nucleic Acid,
pubmed-meshheading:12504852-Trans-Activators,
pubmed-meshheading:12504852-Transcription Factors,
pubmed-meshheading:12504852-Transcriptional Activation
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pubmed:year |
2002
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pubmed:articleTitle |
Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.
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pubmed:affiliation |
Department of Tumor Biology, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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