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rdf:type |
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lifeskim:mentions |
umls-concept:C0004461,
umls-concept:C0006931,
umls-concept:C0007447,
umls-concept:C0027895,
umls-concept:C0030685,
umls-concept:C0035820,
umls-concept:C0205409,
umls-concept:C0391871,
umls-concept:C0439799,
umls-concept:C0445254,
umls-concept:C0596002,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1882884,
umls-concept:C1963578
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pubmed:issue |
3
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pubmed:dateCreated |
2002-12-30
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pubmed:abstractText |
In order to reveal the role of axon reflexes and sensory receptors in sensory neuropeptide release in response to capsaicin, liberation of substance P, calcitonin gene-related peptide and somatostatin from isolated rat tracheae was investigated in the presence of voltage-sensitive Na(+) and Ca(2+) channel blocking agents. Neuropeptide release induced by capsaicin (10 nM) remained unchanged in the presence of 25 mM lidocaine, 1 microM tetrodotoxin or the N-type Ca(2+) channel inhibitor, omega-conotoxin GVIA (100-300 nM). Peptide release by 100 pulses of 2 Hz field stimulation was prevented by lidocaine or tetrodotoxin. Omega-agatoxin TK (250 nM) significantly inhibited and Cd(2+) (200 microM) prevented capsaicin-induced neuropeptide release. These results suggest that chemical stimulation-induced neuropeptide release does not involve activation of fast Na(+) channels or N- and P-type voltage-dependent Ca(2+) channels, but contribution of Q-type Ca(2+) channels is possible. Sensory neuropeptides are released by capsaicin from sensory receptors without axon reflexes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agatoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Cadmium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Lidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Spider Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA,
http://linkedlifedata.com/resource/pubmed/chemical/omega-agatoxin-Aa4b
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
458
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12504788-Agatoxins,
pubmed-meshheading:12504788-Anesthetics, Local,
pubmed-meshheading:12504788-Animals,
pubmed-meshheading:12504788-Axons,
pubmed-meshheading:12504788-Cadmium,
pubmed-meshheading:12504788-Calcitonin Gene-Related Peptide,
pubmed-meshheading:12504788-Calcium Channel Blockers,
pubmed-meshheading:12504788-Calcium Channels,
pubmed-meshheading:12504788-Capsaicin,
pubmed-meshheading:12504788-Dose-Response Relationship, Drug,
pubmed-meshheading:12504788-Electric Stimulation,
pubmed-meshheading:12504788-Female,
pubmed-meshheading:12504788-Lidocaine,
pubmed-meshheading:12504788-Male,
pubmed-meshheading:12504788-Neuropeptides,
pubmed-meshheading:12504788-Rats,
pubmed-meshheading:12504788-Reflex,
pubmed-meshheading:12504788-Sodium Channels,
pubmed-meshheading:12504788-Somatostatin,
pubmed-meshheading:12504788-Spider Venoms,
pubmed-meshheading:12504788-Substance P,
pubmed-meshheading:12504788-Tetrodotoxin,
pubmed-meshheading:12504788-Trachea,
pubmed-meshheading:12504788-omega-Conotoxin GVIA
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pubmed:year |
2003
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pubmed:articleTitle |
Role of voltage-gated cation channels and axon reflexes in the release of sensory neuropeptides by capsaicin from isolated rat trachea.
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pubmed:affiliation |
Neuropharmacology Research Group of the Hungarian Academy of Sciences, Pécs, Hungary.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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