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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-12-30
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pubmed:abstractText |
F-actin polymerization following engagement of the T cell receptor (TCR) is dependent on WASP and is critical for T cell activation. The link between TCR and WASP is not fully understood. In resting cells, WASP exists in a complex with WIP, which inhibits its activation by Cdc42. We show that the adaptor protein CrkL binds directly to WIP. Further, TCR ligation results in the formation of a ZAP-70-CrkL-WIP-WASP complex, which is recruited to lipid rafts and the immunological synapse. TCR engagement also causes PKCtheta-dependent phosphorylation of WIP, causing the disengagement of WASP from the WIP-WASP complex, thereby releasing it from WIP inhibition. These results suggest that the ZAP-70-CrkL-WIP pathway and PKCtheta link TCR to WASP activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/WAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/WIPF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Was protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Waspip protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wiskott-Aldrich Syndrome Protein,
http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C beta
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1269-81
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12504004-Actins,
pubmed-meshheading:12504004-Animals,
pubmed-meshheading:12504004-B-Lymphocytes,
pubmed-meshheading:12504004-Carrier Proteins,
pubmed-meshheading:12504004-Cell Line,
pubmed-meshheading:12504004-Cytoskeletal Proteins,
pubmed-meshheading:12504004-Humans,
pubmed-meshheading:12504004-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12504004-Jurkat Cells,
pubmed-meshheading:12504004-Kinetics,
pubmed-meshheading:12504004-Mice,
pubmed-meshheading:12504004-Mice, Knockout,
pubmed-meshheading:12504004-Protein Kinase C,
pubmed-meshheading:12504004-Protein Transport,
pubmed-meshheading:12504004-Proteins,
pubmed-meshheading:12504004-Receptors, Antigen, T-Cell,
pubmed-meshheading:12504004-T-Lymphocytes,
pubmed-meshheading:12504004-Tumor Cells, Cultured,
pubmed-meshheading:12504004-Wiskott-Aldrich Syndrome,
pubmed-meshheading:12504004-Wiskott-Aldrich Syndrome Protein,
pubmed-meshheading:12504004-cdc42 GTP-Binding Protein
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pubmed:year |
2002
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pubmed:articleTitle |
Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation.
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pubmed:affiliation |
Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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