Source:http://linkedlifedata.com/resource/pubmed/id/12502998
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-12-27
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| pubmed:abstractText |
Systemic lidocaine and other local anesthetics reduce hypersensitivity states induced by both acute inflammation and peripheral nerve injury in animals and produce analgesia in some patients with chronic pain. The mechanisms underlying the antiallodynic effect of systemic lidocaine are unclear, although most focus is on peripheral mechanisms. Central mechanisms, particularly at the spinal dorsal horn level, are less known. In this study, the authors aimed to determine whether intrathecal lidocaine has an antiallodynic effect on established mechanical allodynia in two well-characterized neuropathic pain rat models: partial sciatic nerve ligation (PSNL) and spinal nerve ligation (SNL).
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0003-3022
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
98
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
203-8
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12502998-Anesthetics, Local,
pubmed-meshheading:12502998-Animals,
pubmed-meshheading:12502998-Behavior, Animal,
pubmed-meshheading:12502998-Cyclooxygenase Inhibitors,
pubmed-meshheading:12502998-Dose-Response Relationship, Drug,
pubmed-meshheading:12502998-Drug Synergism,
pubmed-meshheading:12502998-Injections, Spinal,
pubmed-meshheading:12502998-Ketorolac,
pubmed-meshheading:12502998-Lidocaine,
pubmed-meshheading:12502998-Ligation,
pubmed-meshheading:12502998-Male,
pubmed-meshheading:12502998-Pain,
pubmed-meshheading:12502998-Peripheral Nervous System Diseases,
pubmed-meshheading:12502998-Rats,
pubmed-meshheading:12502998-Rats, Sprague-Dawley,
pubmed-meshheading:12502998-Sciatic Nerve,
pubmed-meshheading:12502998-Sciatic Neuropathy,
pubmed-meshheading:12502998-Spinal Nerves
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| pubmed:year |
2003
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| pubmed:articleTitle |
Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
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| pubmed:affiliation |
Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity, Wake Forest university School of Medicine, wisnton Salem, North Carolina 27157-1009, USA. wma@wfubmc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|