Linked Life Data

12499904

Source:http://linkedlifedata.com/resource/pubmed/id/12499904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-12-24
pubmed:abstractText
Perfluorocarbons (PFC) are hydrocarbons in which all or most of the hydrogen atoms have been replaced with fluorine. PFC have a very high capacity for dissolving oxygen (O2 ), and a negligible oxygen-binding constant allows them to release O2 more effectively than hemoglobin into the surrounding tissue. As a result of this unique property, PFC-based solutions have been examined as oxygen carriers. PFC was first used for organ preservation as a component of the two-layer method (TLM) (University of Wisconsin [UW] solution-perfluorochemical plus oxygen) of pancreas preservation. Pancreata preserved in the TLM are oxygenated through the PFC and substrates are supplied by the UW solution. This allows pancreata stored in the TLM to generate adenosine triphosphate during storage and prolong the preservation period. In the canine model, TLM has been shown to repair and resuscitate warm ischemically injured pancreata during preservation, improve pancreas graft survival after transplantation, and improve islet yields after isolation. Current clinical trials using the TLM of pancreas preservation before whole-pancreas transplantation and islet isolation show promising results. The TLM has also been shown to be beneficial for preserving other difficult organs, such as heart and small bowel.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1804-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Perfluorocarbon for organ preservation before transplantation.
pubmed:affiliation
Islet and Cell Processing Laboratory, Puget Sound Blood Center/Northwest Tissue Center, Seattle, WA, USA. shinichi@kuhp.Kyoto-u.ac.jp.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't