Source:http://linkedlifedata.com/resource/pubmed/id/12498780
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-12-24
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| pubmed:abstractText |
Bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) are potential therapeutic molecules for the treatment of Parkinson's disease (PO). Here we compare the effects of BMP3, 5, 6, and 7 and GDF5 and 6 in a rat mesencephalic cell culture system that reflects the developmental stage of neurons around birth. High concentrations of BMP5, 6, and 7 and GDF5 and 6 induced astroglial cell fate and a depletion of oligodendrocytes. Only BMP5, 6, and 7, however, significantly increased the number of tyrosine hydroxylase (TH)-positive neurons and induced nuclear translocation of the phosphorylated BMP-restricted Smad in a substantial number of TH- and microtubule-associated protein 2(MAP2ab)-positive cells. None of the proteins protected TH-positive cells against 6-hydroxydopamine-induced oxidative stress. BMP3 was without any effect throughout the studies. We conclude that BMP5, 6, and 7 act directly and independently on precursors of the dopaminergic and astroglial lineage and induce their differentiation. In contrast, GDF5 and 6 primarily affect nonneuronal cells in mesencephalic cultures of this stage.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1044-7431
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
367-78
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12498780-Animals,
pubmed-meshheading:12498780-Bone Morphogenetic Proteins,
pubmed-meshheading:12498780-Brain Tissue Transplantation,
pubmed-meshheading:12498780-Cell Differentiation,
pubmed-meshheading:12498780-Cell Survival,
pubmed-meshheading:12498780-Cells, Cultured,
pubmed-meshheading:12498780-Dopamine,
pubmed-meshheading:12498780-Dose-Response Relationship, Drug,
pubmed-meshheading:12498780-Fetus,
pubmed-meshheading:12498780-Graft Survival,
pubmed-meshheading:12498780-Growth Substances,
pubmed-meshheading:12498780-Neurons,
pubmed-meshheading:12498780-Neuroprotective Agents,
pubmed-meshheading:12498780-Oligodendroglia,
pubmed-meshheading:12498780-Oxidopamine,
pubmed-meshheading:12498780-Parkinson Disease,
pubmed-meshheading:12498780-Rats,
pubmed-meshheading:12498780-Rats, Sprague-Dawley,
pubmed-meshheading:12498780-Stem Cells,
pubmed-meshheading:12498780-Substantia Nigra,
pubmed-meshheading:12498780-Tyrosine 3-Monooxygenase
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| pubmed:year |
2002
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| pubmed:articleTitle |
Bone morphogenetic proteins but not growth differentiation factors induce dopaminergic differentiation in mesencephalic precursors.
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| pubmed:affiliation |
Institute of Anatomy and Cell Biology, Göteborg University, SE 40530, Göteborg, Sweden. anke.brederlau@anatcell.gu.se
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|