Fibrates induce hepatic peroxisome proliferation and carcinogenesis in rodents by activating peroxisome proliferator-activated receptor alpha (PPAR(alpha)). There is no conclusive evidence that humans are unresponsive to peroxisome proliferation, and concern exists about the long-term safety of fibrate treatment.
Pharmacology Unit, Faculty of Pharmacy, University of Barcelona, Surgical Department and Lipid Clinic, Nutrition and Dietetics Service, Hospital Clínic i Provincial, Spain.
