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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-23
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pubmed:abstractText |
IL-2 and IL-15 are thought to be important cytokines for T cell-dependent immune responses. Mice deficient in IL-2, IL-2Ralpha, and IL-2Rbeta are each characterized by a rapid lethal autoimmune lymphoproliferative disorder that complicates their use in studies aimed at investigating the role of these cytokines and receptors for immune responses in vivo. We have previously characterized a novel transgenic (Tg) mouse on the IL-2Rbeta-/- genetic background (Tg-/- mice) that lacks autoimmune disease but still contains peripheral T cells that are nonresponsive to IL-2 and IL-15. In the present study, these mice were used to investigate the extent by which IL-2 and IL-15 are essential for T cell immunity in vivo. Tg-/- mice generated near normal primary and secondary Ab responses to OVA, readily mounted first and second set allogeneic skin graft rejection responses, and developed primary and recall CD8 T cell responses to vaccinia virus. However, Tg-/- mice generated a slightly lower level of IgG2a Abs to OVA, exhibited a somewhat delayed first set skin graft rejection response with lower allo-specific CTL, and developed a significantly lower number of IFN-gamma-producing vaccinia-specific CD8+ T cells. Thus, although T effector function is somewhat impaired, T cell immunity is largely functional in the absence of IL-2- and IL-15-induced signaling through IL-2Rbeta.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Il15ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
236-42
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12496405-Animals,
pubmed-meshheading:12496405-Antibodies, Monoclonal,
pubmed-meshheading:12496405-Antibody Formation,
pubmed-meshheading:12496405-Antigens, CD3,
pubmed-meshheading:12496405-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12496405-Cytotoxicity, Immunologic,
pubmed-meshheading:12496405-Graft Rejection,
pubmed-meshheading:12496405-Immunization,
pubmed-meshheading:12496405-Immunization, Secondary,
pubmed-meshheading:12496405-Immunoglobulin G,
pubmed-meshheading:12496405-Interleukin-15,
pubmed-meshheading:12496405-Lymphocyte Activation,
pubmed-meshheading:12496405-Mice,
pubmed-meshheading:12496405-Mice, Inbred BALB C,
pubmed-meshheading:12496405-Mice, Inbred C57BL,
pubmed-meshheading:12496405-Mice, Transgenic,
pubmed-meshheading:12496405-Murine hepatitis virus,
pubmed-meshheading:12496405-Ovalbumin,
pubmed-meshheading:12496405-Receptors, Interleukin-15,
pubmed-meshheading:12496405-Receptors, Interleukin-2,
pubmed-meshheading:12496405-Skin Transplantation,
pubmed-meshheading:12496405-T-Lymphocyte Subsets,
pubmed-meshheading:12496405-Transplantation, Homologous,
pubmed-meshheading:12496405-Vaccinia virus
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pubmed:year |
2003
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pubmed:articleTitle |
Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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