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rdf:type |
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lifeskim:mentions |
umls-concept:C0021755,
umls-concept:C0027540,
umls-concept:C0037083,
umls-concept:C0127400,
umls-concept:C0387030,
umls-concept:C0439855,
umls-concept:C0530129,
umls-concept:C1334137,
umls-concept:C1336666,
umls-concept:C1514873,
umls-concept:C1521761,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1704675,
umls-concept:C1710082
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pubmed:issue |
13
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pubmed:dateCreated |
2003-3-24
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pubmed:abstractText |
The signaling pathway downstream of the mammalian interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) is evolutionally conserved with that mediated by the Drosophila Toll protein. Toll initiates its signal through the adapter molecule Tube and the serine-threonine kinase Pelle. Pelle is highly homologous to members of the IL-1R-associated kinase (IRAK) family in mammals. Recently, a novel Pelle-interacting protein called Pellino was identified in Drosophila. We now report a mammalian counterpart of Pellino, termed Pellino 1, which is required for NF kappa B activation and IL-8 gene expression in response to IL-1, probably through its signal-dependent interaction with IRAK4, IRAK, and the tumor necrosis factor receptor-associated factor 6 (TRAF6). The Pellino 1-IRAK-IRAK4-TRAF6 signaling complex is likely to be intermediate, located between the IL-1 receptor complex and the TAK1 complex in the IL-1 pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PELI1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10952-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12496252-Amino Acid Sequence,
pubmed-meshheading:12496252-DNA, Complementary,
pubmed-meshheading:12496252-Gene Expression Regulation,
pubmed-meshheading:12496252-Humans,
pubmed-meshheading:12496252-Interleukin-1,
pubmed-meshheading:12496252-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:12496252-Interleukin-8,
pubmed-meshheading:12496252-Molecular Sequence Data,
pubmed-meshheading:12496252-NF-kappa B,
pubmed-meshheading:12496252-Nuclear Proteins,
pubmed-meshheading:12496252-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:12496252-Precipitin Tests,
pubmed-meshheading:12496252-Proteins,
pubmed-meshheading:12496252-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12496252-Recombinant Proteins,
pubmed-meshheading:12496252-Sequence Homology, Amino Acid,
pubmed-meshheading:12496252-Signal Transduction,
pubmed-meshheading:12496252-TNF Receptor-Associated Factor 6
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pubmed:year |
2003
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pubmed:articleTitle |
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
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pubmed:affiliation |
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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