| pubmed-article:12496177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12496177 | lifeskim:mentions | umls-concept:C0683626 | lld:lifeskim |
| pubmed-article:12496177 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:12496177 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:12496177 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12496177 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12496177 | lifeskim:mentions | umls-concept:C0127526 | lld:lifeskim |
| pubmed-article:12496177 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12496177 | pubmed:dateCreated | 2002-12-23 | lld:pubmed |
| pubmed-article:12496177 | pubmed:abstractText | Serum bactericidal activity confers protection against meningococcal disease, but it is not known whether vaccine-induced anticapsular antibodies that lack bactericidal activity are protective. We developed an infant rat challenge model using a naturally occurring O-acetylated strain of Neisseria meningitidis group C and a strain that was negative for O acetylation (OAc). Rats 4 to 7 days of age inoculated intraperitoneally (i.p.) with approximately 10(3) CFU of either strain developed >5 x 10(5) CFU/ml of blood obtained 18 h later. Dilutions of preimmunization sera given i.p. 2 h before the bacterial challenge had no effect on bacteremia, whereas group C anticapsular antibody in sera from adults immunized with meningococcal polysaccharide vaccine conferred complete or partial (>99% decrease in CFU per milliliter of blood) protection against the OAc-positive or OAc-negative strain, respectively, at antibody doses as low as 0.04 micro g/rat. Anticapsular antibody at doses fivefold higher (0.18 to 0.2 micro g/rat) in pooled sera from children immunized at a mean age of 2.6 years failed to protect rats, but antibody at the same or fivefold-lower dose in a serum pool from a group of children immunized at 4 years of age gave complete or partial protection. Protective activity was observed with some serum pools that lacked detectable complement-mediated bactericidal activity (titers < 1:4) and correlated with increasing antibody avidity. Thus, not only does the magnitude of the group C antibody response to meningococcal polysaccharide vaccine increase with increasing age but there are also age-related affects on antibody functional activity such that higher serum concentrations of vaccine-induced antibody are required for protection of immunized children than for immunized adults. | lld:pubmed |
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| pubmed-article:12496177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12496177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12496177 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12496177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12496177 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12496177 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:12496177 | pubmed:author | pubmed-author:GranoffDan... | lld:pubmed |
| pubmed-article:12496177 | pubmed:author | pubmed-author:HarrisShannon... | lld:pubmed |
| pubmed-article:12496177 | pubmed:author | pubmed-author:FerrisWendyW | lld:pubmed |
| pubmed-article:12496177 | pubmed:author | pubmed-author:KingW JamesWJ | lld:pubmed |
| pubmed-article:12496177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12496177 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:12496177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12496177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12496177 | pubmed:pagination | 275-86 | lld:pubmed |
| pubmed-article:12496177 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12496177 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12496177 | pubmed:articleTitle | Age-related disparity in functional activities of human group C serum anticapsular antibodies elicited by meningococcal polysaccharide vaccine. | lld:pubmed |
