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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-12-23
pubmed:abstractText
Serum bactericidal activity confers protection against meningococcal disease, but it is not known whether vaccine-induced anticapsular antibodies that lack bactericidal activity are protective. We developed an infant rat challenge model using a naturally occurring O-acetylated strain of Neisseria meningitidis group C and a strain that was negative for O acetylation (OAc). Rats 4 to 7 days of age inoculated intraperitoneally (i.p.) with approximately 10(3) CFU of either strain developed >5 x 10(5) CFU/ml of blood obtained 18 h later. Dilutions of preimmunization sera given i.p. 2 h before the bacterial challenge had no effect on bacteremia, whereas group C anticapsular antibody in sera from adults immunized with meningococcal polysaccharide vaccine conferred complete or partial (>99% decrease in CFU per milliliter of blood) protection against the OAc-positive or OAc-negative strain, respectively, at antibody doses as low as 0.04 micro g/rat. Anticapsular antibody at doses fivefold higher (0.18 to 0.2 micro g/rat) in pooled sera from children immunized at a mean age of 2.6 years failed to protect rats, but antibody at the same or fivefold-lower dose in a serum pool from a group of children immunized at 4 years of age gave complete or partial protection. Protective activity was observed with some serum pools that lacked detectable complement-mediated bactericidal activity (titers < 1:4) and correlated with increasing antibody avidity. Thus, not only does the magnitude of the group C antibody response to meningococcal polysaccharide vaccine increase with increasing age but there are also age-related affects on antibody functional activity such that higher serum concentrations of vaccine-induced antibody are required for protection of immunized children than for immunized adults.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10217596, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10225896, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10395878, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10603394, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10694002, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10783023, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10838647, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10865169, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-10982066, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11119522, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11176810, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11179328, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11213098, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11214233, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11329468, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11349041, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11443568, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11587814, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-118997, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-11988262, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-1202084, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-1538539, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-163259, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-1937795, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-2342828, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-2786040, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-3373019, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-3485275, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-4621363, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-4977280, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-4977281, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-4983754, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-7697519, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-7706754, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-8419487, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-8622225, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-8636811, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-8920699, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9008844, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9067649, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9466635, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9534995, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9596702, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9665952, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9728562, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9832000, http://linkedlifedata.com/resource/pubmed/commentcorrection/12496177-9844044
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-86
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:12496177-Adolescent, pubmed-meshheading:12496177-Adult, pubmed-meshheading:12496177-Aging, pubmed-meshheading:12496177-Animals, pubmed-meshheading:12496177-Animals, Newborn, pubmed-meshheading:12496177-Antibodies, Bacterial, pubmed-meshheading:12496177-Antibody Affinity, pubmed-meshheading:12496177-Bacteremia, pubmed-meshheading:12496177-Bacterial Capsules, pubmed-meshheading:12496177-Blood Bactericidal Activity, pubmed-meshheading:12496177-Child, pubmed-meshheading:12496177-Child, Preschool, pubmed-meshheading:12496177-Disease Models, Animal, pubmed-meshheading:12496177-Humans, pubmed-meshheading:12496177-Immunization, Passive, pubmed-meshheading:12496177-Infant, pubmed-meshheading:12496177-Meningococcal Infections, pubmed-meshheading:12496177-Meningococcal Vaccines, pubmed-meshheading:12496177-Neisseria meningitidis, Serogroup C, pubmed-meshheading:12496177-Rats, pubmed-meshheading:12496177-Rats, Wistar
pubmed:year
2003
pubmed:articleTitle
Age-related disparity in functional activities of human group C serum anticapsular antibodies elicited by meningococcal polysaccharide vaccine.
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