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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-12-23
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pubmed:abstractText |
Methylenecyclobutane analogues of 2'-deoxyadenosine, 2'-deoxyguanosine and 2'-deoxycytidine, and the corresponding phosphoralaninate pronucleotides comprising adenine and guanine bases, were synthesized as potential antiviral agents. Phosphoralaninate of adenine methylenecyclobutane was a potent inhibitor of replication of Epstein-Barr virus (EBV) in Daudi cell culture. Phosphoralaninate of guanine analogue was inactive but both pronucleotides were substrates for porcine liver esterase. Adenine methylenecyclobutane analogue was deaminated by adenosine deaminase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0956-3202
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12495213-Adenosine Deaminase,
pubmed-meshheading:12495213-Alanine,
pubmed-meshheading:12495213-Animals,
pubmed-meshheading:12495213-Antiviral Agents,
pubmed-meshheading:12495213-Cell Line,
pubmed-meshheading:12495213-Cyclobutanes,
pubmed-meshheading:12495213-Deamination,
pubmed-meshheading:12495213-Esterases,
pubmed-meshheading:12495213-Fibroblasts,
pubmed-meshheading:12495213-Herpesvirus 4, Human,
pubmed-meshheading:12495213-Humans,
pubmed-meshheading:12495213-Lethal Dose 50,
pubmed-meshheading:12495213-Liver,
pubmed-meshheading:12495213-Nucleosides,
pubmed-meshheading:12495213-Prodrugs,
pubmed-meshheading:12495213-Stereoisomerism,
pubmed-meshheading:12495213-Structure-Activity Relationship,
pubmed-meshheading:12495213-Swine
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: a new pronucleotide effective against Epstein-Barr virus.
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pubmed:affiliation |
Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Mich, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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