Source:http://linkedlifedata.com/resource/pubmed/id/12494432
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-12-20
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| pubmed:abstractText |
A fetus with trisomy 8 mosaicism was identified prenatally due to an abnormal maternal serum triple screen. Tissue samples were taken at birth to determine the level of trisomy 8 mosaicism found within embryonic and extra-embryonic tissues, rates of cell division for the two cell lines, and the effect of mosaicism on the phenotype. The level of trisomy 8 cells in blood and fibroblasts was higher than in placental tissue. Cell cycle kinetics, by incorporation of bromodeoxyuridine for 48 hr, was not significantly different between the trisomy 8 and normal cells for blood or amnion. Fluorescent in situ hybridization (FISH) using centromeric probe for chromosome 8 showed significantly more trisomy 8 in interphase vs. metaphase in lymphoblasts, umbilical cord fibroblasts, and chorion. The loss of trisomy 8 cells is not due to anaphase lag, as determined by micronuclei analysis. The similarity of cell cycle kinetics between trisomy 8 cells and normal diploid cells suggests some trisomy 8 cells are exiting the cell cycle prematurely. This growth disadvantage of trisomy 8 cells results in the appearance of growth advantage for diploid cells.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1552-4825
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
116A
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
144-6
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| pubmed:dateRevised |
2008-5-21
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| pubmed:meshHeading |
pubmed-meshheading:12494432-Amnion,
pubmed-meshheading:12494432-Blood Cells,
pubmed-meshheading:12494432-Cell Cycle,
pubmed-meshheading:12494432-Cell Division,
pubmed-meshheading:12494432-Cells, Cultured,
pubmed-meshheading:12494432-Chromosomes, Human, Pair 8,
pubmed-meshheading:12494432-Fetus,
pubmed-meshheading:12494432-Humans,
pubmed-meshheading:12494432-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12494432-Karyotyping,
pubmed-meshheading:12494432-Male,
pubmed-meshheading:12494432-Mosaicism,
pubmed-meshheading:12494432-Trisomy,
pubmed-meshheading:12494432-Umbilical Cord
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| pubmed:year |
2003
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| pubmed:articleTitle |
Trisomy 8 mosaicism: selective growth advantage of normal cells vs. growth disadvantage of trisomy 8 cells.
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| pubmed:affiliation |
Genetics and Developmental Biology Program, West Virginia University, Morgantown, West Virginia 26506-9203, USA.
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| pubmed:publicationType |
Journal Article
|