Linked Life Data

12494183

Source:http://linkedlifedata.com/resource/pubmed/id/12494183

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-12-20
pubmed:abstractText
One hundred nine patients with essential hypertension were studied (50 male and 59 female, mean age - 62,6-/+1,08 years). Seventy six patients had left ventricular hypertrophy measured by echocardiography. NOS3 polymorphisms (Glu298Asp and ecNOS4a/4b) were studied by PCR. In patients without left ventricular hypertrophy (LVH) genotypes frequencies of NOS3 (Glu298Asp) were: Glu/Glu - 34.4%; Glu/Asp - 62,5%; Asp/Asp - 3,1%. In patients with LVH - Glu/Glu - 55.3%; Glu/Asp - 40.8%; Asp/Asp - 3.9%; p=0,117. Percent of Glu/Glu genotype was significantly higher in LVH group (p=0,047). Genotypes frequencies of ecNOS4a/4b were: in patients without LVH - 4b/4b - 37,5%; 4a/4b - 62,5%; 4a/4a - 0; in patients with LVH - 4b/4b - 21.1%; 4a/4b - 76.3%; 4a/4a - 2,6%;. p=0,151. Patients with 4a allele had higher Amax than 4b/4b patients (76,3+2,11 m/s and 67,9+4,72 m/s; p=0,040). Therefore, we show associations between Glu allele of NOS3 (Glu298Asp) and left ventricular hypertrophy and between 4a allele (ecNOS4a/4b) and diastolic dysfunction in patients with essential hypertension.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0022-9040
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
30-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[NOS3 gene polymorphism and left ventricular hypertrophy in patients with essential hypertension].
pubmed:publicationType
Journal Article, English Abstract