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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-3-28
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pubmed:databankReference |
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pubmed:abstractText |
The most common form of hypersensitivity pneumonitis in Japan is summer-type hypersensitivity pneumonitis (SHP), which is caused by the inhalation of Trichosporon asahii or Trichosporon mucoides. To seek protein antigens relevant to the immunopathogenesis of SHP, we constructed a cDNA expression library of T. asahii, a major causative yeast species of SHP. Using the immunoscreening method, we identified and cloned a novel gene encoding a 19-kD protein, named TA-19, which proved to be specifically recognized in the bronchoalveolar lavage (BAL) fluids and sera of patients with SHP. IgG, IgA, and IgM antibodies to the recombinant TA-19 protein were significantly elevated in the sera as well as in the BAL fluids from SHP patients compared with those from non-SHP groups. This protein also induced SHP-specific proliferation of the mononuclear cells from both the peripheral blood and BAL. These results reveal that TA-19 derived from T. asahii may play a relevant role in specific cellular and humoral immune responses in patients with SHP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1073-449X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
991-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12493647-Administration, Inhalation,
pubmed-meshheading:12493647-Adult,
pubmed-meshheading:12493647-Aged,
pubmed-meshheading:12493647-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:12493647-Antibodies, Fungal,
pubmed-meshheading:12493647-Antibody Specificity,
pubmed-meshheading:12493647-Antigens, Fungal,
pubmed-meshheading:12493647-Base Sequence,
pubmed-meshheading:12493647-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:12493647-Female,
pubmed-meshheading:12493647-Gene Expression Regulation, Fungal,
pubmed-meshheading:12493647-Gene Library,
pubmed-meshheading:12493647-Humans,
pubmed-meshheading:12493647-Immunoglobulin A,
pubmed-meshheading:12493647-Immunoglobulin G,
pubmed-meshheading:12493647-Immunoglobulin M,
pubmed-meshheading:12493647-Japan,
pubmed-meshheading:12493647-Lymphocytosis,
pubmed-meshheading:12493647-Male,
pubmed-meshheading:12493647-Middle Aged,
pubmed-meshheading:12493647-Molecular Sequence Data,
pubmed-meshheading:12493647-Nucleic Acid Amplification Techniques,
pubmed-meshheading:12493647-Predictive Value of Tests,
pubmed-meshheading:12493647-Recombinant Proteins,
pubmed-meshheading:12493647-Seasons,
pubmed-meshheading:12493647-Trichosporon
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pubmed:year |
2003
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pubmed:articleTitle |
TA-19, a novel protein antigen of Trichosporon asahii, in summer-type hypersensitivity pneumonitis.
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pubmed:affiliation |
Department of Pulmonary Medicine, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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