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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-20
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pubmed:abstractText |
Induction of heme oxygenase-1 (HO-1) in the spinal cord was studied in adult wildtype and transgenic mice overexpressing the antioxidant copper, zinc superoxide dismutase (CuZn SOD) 24 h after intrathecal infusion of heterologous lysed blood. Double immunolabeling techniques were used to determine the extent to which HO-1 was induced in astrocytes and microglia/macrophages. HO-1 was induced in both astrocytes and microglia/macrophages in the dorsal horns near the site of infusion of lysed blood in all mice. However, the number of HO-1 labeled cells was significantly less in the transgenic as compared to the wildtype animals. Together, these findings suggest that lysed blood preferentially induces HO-1 in glia and macrophages through the generation of oxidative stress.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
336
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12493591-Animals,
pubmed-meshheading:12493591-Antigens, CD11b,
pubmed-meshheading:12493591-Blood,
pubmed-meshheading:12493591-Blood Proteins,
pubmed-meshheading:12493591-Enzyme Activation,
pubmed-meshheading:12493591-Glial Fibrillary Acidic Protein,
pubmed-meshheading:12493591-Heme Oxygenase (Decyclizing),
pubmed-meshheading:12493591-Heme Oxygenase-1,
pubmed-meshheading:12493591-Immunohistochemistry,
pubmed-meshheading:12493591-Injections, Spinal,
pubmed-meshheading:12493591-Membrane Proteins,
pubmed-meshheading:12493591-Mice,
pubmed-meshheading:12493591-Mice, Transgenic,
pubmed-meshheading:12493591-Oxidative Stress,
pubmed-meshheading:12493591-Random Allocation,
pubmed-meshheading:12493591-Spinal Cord,
pubmed-meshheading:12493591-Superoxide Dismutase
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pubmed:year |
2003
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pubmed:articleTitle |
Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase.
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pubmed:affiliation |
Department of Neurological Surgery, RWTH Aachen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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