|
rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-12-19
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pubmed:abstractText |
Many class III antiarrhythmic agents lose efficacy under beta-adrenergic stimulation and at high heart rates (reverse rate dependence). This effect is thought to be due to selective blockade of the rapidly (I(Kr)), but not the slowly (I(Ks)), activating component of the delayed inward rectifier potassium current. Azimilide is an investigational class III antiarrhythmic agent that blocks both IKr and IKs.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
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|
pubmed:issn |
1074-2484
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12490966-Action Potentials,
pubmed-meshheading:12490966-Adrenergic beta-Agonists,
pubmed-meshheading:12490966-Adult,
pubmed-meshheading:12490966-Aged,
pubmed-meshheading:12490966-Anti-Arrhythmia Agents,
pubmed-meshheading:12490966-Drug Synergism,
pubmed-meshheading:12490966-Female,
pubmed-meshheading:12490966-Humans,
pubmed-meshheading:12490966-Imidazoles,
pubmed-meshheading:12490966-Imidazolidines,
pubmed-meshheading:12490966-Isoproterenol,
pubmed-meshheading:12490966-Male,
pubmed-meshheading:12490966-Middle Aged,
pubmed-meshheading:12490966-Piperazines,
pubmed-meshheading:12490966-Single-Blind Method,
pubmed-meshheading:12490966-Ventricular Fibrillation,
pubmed-meshheading:12490966-Ventricular Function, Right
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|
pubmed:year |
2002
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|
pubmed:articleTitle |
The effect of isoproterenol on the class III effect of azimilide in humans.
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|
pubmed:affiliation |
Department of Medicine, St. Michael's Hospital, Toronto, Canada.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
