Linked Life Data

12489806

Source:http://linkedlifedata.com/resource/pubmed/id/12489806

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13-14
pubmed:dateCreated
2002-12-19
pubmed:abstractText
High-molecular-weight kininogen (HK) is a plasma protein consisting of six domains (designated D1-D6). It was first characterized as a precursor of bradykinin, a bioactive peptide that regulates many cardiovascular processes. HK can bind to endothelial cells where it can be cleaved by plasma kallikrein to release bradykinin contained within domain 4. The remaining portion of the molecule, cleaved HK, is designated HKa. While bradykinin has been intensively studied, the physiological implication of the generation of HKa is not clear. HKa has recently been shown to inhibit the important steps required for angiogenesis such as proliferation and migration of endothelial cells. The antiangiogenic activity of HKa has further been demonstrated in animal models in which HKa inhibits neovascularization. Because domain 5 (D5) of HKa reproduces the antiangiogenic effect of HKa, D5 is named kininostatin for this novel function. In this review, we will briefly discuss the recent progress in the studies of the molecular mechanisms that mediate the antiangiogenic effect of HKa and D5.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1567-5769
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1931-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Kininostatin as an antiangiogenic inhibitor: what we know and what we do not know.
pubmed:affiliation
The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA. yguo0002@astro.temple.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't