Linked Life Data

12488828

Source:http://linkedlifedata.com/resource/pubmed/id/12488828

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2002-12-18
pubmed:abstractText
Within the nucleus tractus solitarii (NTS), serotonin (5-HT) exerts modulatory effects on central mechanisms controlling autonomic functions, notably through the stimulation of 5-HT2 receptors. Using double immunocytochemical labeling with specific anti-5-HT2A receptor antibodies and antibodies directed against the catecholamine (CA) synthesizing enzymes, i.e. tyrosine hydroxylase, dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase, we investigated whether 5-HT effects could be mediated by 5-HT2A receptors located on CA perikarya and/or processes within the NTS. A relatively high density of 5-HT2A immunoreactive processes was observed throughout the NTS. 5-HT2A neuronal perikarya were also found within the NTS except in its rostrolateral part. Double immunolabeling experiments revealed many 5-HT2A receptors on CA processes but only few 5-HT2A/TH and 5-HT2A/DBH perikarya. These data support the idea that, within the NTS, 5-HT2A-mediated control of autonomic functions involves CA neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2365-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
5-HT2A receptors are expressed by catecholaminergic neurons in the rat nucleus tractus solitarii.
pubmed:affiliation
INSERM U288, NeuroPsychoPharmacologie, Faculté de Médecine Pitié-Salpêtrière, 75634 Paris Cedex 13, France. nosjean@ext.jussieu.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't