Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-12-18
pubmed:abstractText
Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. To date, four histamine receptors have been identified, and the H3 receptor, which was recently cloned, is predominantly expressed in the CNS. The peripheral functions of histamine have been investigated intensively using available molecular and pharmacological tools, and the molecular identification of the H3 receptor opens up new possibilities for investigating the role of histamine in central tissues. To understand the biological function of the histamine presynaptic autoreceptor H3, we inactivated the receptor through homologous recombination. H3(-/-) mice manifest mild obese phenotypes that are characterized by increases in body weight, food intake, and adiposity and by reductions in energy expenditure. Consistent with these observations, homozygous null mice have insulin and leptin resistance, increased levels of plasma leptin and insulin, and decreased levels of histamine in the hypothalamic/thalamic region of their brains coupled with increased histamine turnover. The expression of UCP1 in brown adipose tissue and of UCP3 in brown adipose tissue, white adipose tissue, and skeletal muscle is decreased in H3(-/-) mutants, and the anorexigenic activity of thioperamide is not observed. These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-10347254, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-10385696, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-10481909, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-10580415, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-10868929, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-10973974, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-11080193, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-11272150, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-11272151, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-11459437, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-12114623, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-1330211, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-1846044, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-2164693, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-2169324, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-2564258, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-7494855, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8012834, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8020871, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8313152, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8564266, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8620607, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8917588, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8939859, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-8982515, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9225331, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9367152, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9512082, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9570327, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9630675, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9648822, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9652190, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9861026, http://linkedlifedata.com/resource/pubmed/commentcorrection/12488429-9872314
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1791-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12488429-Animals, pubmed-meshheading:12488429-Biological Markers, pubmed-meshheading:12488429-Body Weight, pubmed-meshheading:12488429-Brain, pubmed-meshheading:12488429-Eating, pubmed-meshheading:12488429-Female, pubmed-meshheading:12488429-Gene Targeting, pubmed-meshheading:12488429-Histamine, pubmed-meshheading:12488429-Histamine Antagonists, pubmed-meshheading:12488429-Homeostasis, pubmed-meshheading:12488429-Insulin, pubmed-meshheading:12488429-Leptin, pubmed-meshheading:12488429-Male, pubmed-meshheading:12488429-Mice, pubmed-meshheading:12488429-Mice, Inbred C57BL, pubmed-meshheading:12488429-Mice, Knockout, pubmed-meshheading:12488429-Motor Activity, pubmed-meshheading:12488429-Muscle, Skeletal, pubmed-meshheading:12488429-Neurons, pubmed-meshheading:12488429-Obesity, pubmed-meshheading:12488429-Phenotype, pubmed-meshheading:12488429-Piperidines, pubmed-meshheading:12488429-Receptors, Histamine H3
pubmed:year
2002
pubmed:articleTitle
Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype.
pubmed:affiliation
Functional Genomics, Banyu Tsukuba Research Institute, Tsukuba, Ibaraki, Japan.
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