Source:http://linkedlifedata.com/resource/pubmed/id/12487384
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-12-18
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| pubmed:abstractText |
The prevalence of lipodystrophy in an HIV-infected population and the risk factors associated with body shape changes were analysed in this study. Five hundred and four subjects were included. Among these, 201 (39.9%) had features of lipodystrophy syndrome (cases); 303 (60.1%) constituted the control group. Compared with the control group, the lipodystrophy subjects were different in age (P = 0.01); duration of antiretroviral therapy (P < 0.001); length of exposure to nucleoside reverse transcriptase inhibitors (NRTIs) (P < 0.001) and to protease inhibitors (P < 0.001); nadir of CD4 cell count (P < 0.001); and value of plasma HIV-RNA before antiretroviral therapy (P = 0.008). In a multivariate analysis, length of therapy and a nadir CD4 cell count below 250 cell/microl were associated with an increased risk of lipodystrophy. Among patients with lipodystrophy, isolated fat loss was observed in 46 (23%); isolated fat accumulation in 40 (20%); mixed (loss and accumulation) syndrome in 50 (25%); and isolated metabolic changes in 65 (32%). Subjects with morphological alterations displayed a greater cumulative time of exposure to NRTIs and to protease inhibitors than patients with isolated metabolic alterations. Patients with lipoatrophy had had a greater exposure to stavudine.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
1359-6535
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
175-80
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12487384-Adolescent,
pubmed-meshheading:12487384-Adult,
pubmed-meshheading:12487384-Age Factors,
pubmed-meshheading:12487384-Aged,
pubmed-meshheading:12487384-Anti-HIV Agents,
pubmed-meshheading:12487384-CD4 Lymphocyte Count,
pubmed-meshheading:12487384-Cohort Studies,
pubmed-meshheading:12487384-Drug Administration Schedule,
pubmed-meshheading:12487384-Female,
pubmed-meshheading:12487384-HIV,
pubmed-meshheading:12487384-HIV Infections,
pubmed-meshheading:12487384-HIV-Associated Lipodystrophy Syndrome,
pubmed-meshheading:12487384-Humans,
pubmed-meshheading:12487384-Logistic Models,
pubmed-meshheading:12487384-Male,
pubmed-meshheading:12487384-Middle Aged,
pubmed-meshheading:12487384-Prevalence,
pubmed-meshheading:12487384-RNA, Viral,
pubmed-meshheading:12487384-Risk Factors
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Evaluation of the risk factors associated with lipodystrophy development in a cohort of HIV-positive patients.
|
| pubmed:affiliation |
Infectious Disease Department, IRCCS, Policlinico S. Matteo Hospital, University of Pavia, Pavia, Italy.
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| pubmed:publicationType |
Journal Article
|