Linked Life Data

12486148

Source:http://linkedlifedata.com/resource/pubmed/id/12486148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2002-12-17
pubmed:abstractText
In the retina, AII (rod) amacrine cells are essential for integrating rod signals into the cone pathway. In addition to being interconnected via homologous gap junctions, these cells make extensive heterologous gap junctions with ON-cone bipolar cells (BCs). These gap junctions are the pathway for transfer of rod signals to the ON-system. To investigate the functional properties of these gap junctions, we performed simultaneous whole-cell recordings from pairs of AII amacrine cells and ON-cone bipolar cells in the in vitro slice preparation of the rat retina. We demonstrate strong electrical coupling with symmetrical junction conductance (approximately 1.2 nS) and very low steady-state voltage sensitivity. However, signal transmission is more effective in the direction from AII amacrine cells to ON-cone bipolar cells than in the other direction. This functional rectification can be explained by a corresponding difference in membrane input resistance between the two cell types. Signal transmission has low-pass filter characteristics with increasing attenuation and phase shift for increasing stimulus frequency. Action potentials in AII amacrine cells evoke distinct electrical postsynaptic potentials in ON-cone bipolar cells. Strong and temporally precise synchronization of subthreshold membrane potential fluctuations are commonly observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10558-66
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Electrical synapses mediate signal transmission in the rod pathway of the mammalian retina.
pubmed:affiliation
University of Bergen, Department of Anatomy and Cell Biology, N-5009 Bergen, Norway.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't